ArticleClinical and experimental immunology2005
Anisakis simplex allergy: a murine model of anaphylaxis induced by parasitic proteins displays a mixed Th1/Th2 pattern.
Article in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Alterations in immunized antigens of Anisakis pegreffii by ampicillin-induced gut microbiome changes in mice.Parasites, hosts and diseases · 2024Article
- What Do In Vitro and In Vivo Models Tell Us about Anisakiasis? New Tools Still to Be Explored.Pathogens (Basel, Switzerland) · 2022Review
- Article
- Genera and Species of the Anisakidae Family and Their Geographical Distribution.Animals : an open access journal from MDPI · 2020Review
- Immune response evaluation inVeterinary world · 2019Article
- Molecular and Cellular Response to ExperimentalFrontiers in immunology · 2018Article
- Pathogenic Potential of Fresh, Frozen, and Thermally TreatedJournal of nematology · 2017Article
- Anisakis haemoglobin is a main antigen inducing strong and prolonged immunoreactions in rats.Parasitology research · 2017Article
- Allergenic activity of Pseudoterranova decipiens (Nematoda: Anisakidae) in BALB/c mice.Parasites & vectors · 2017Article
- Cytokine signature and antibody-mediated response against fresh and attenuated Anisakis simplex (L3) administration into Wistar rats: implication for anti-allergic reaction.Parasitology research · 2015Article
- Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay.Clinical and vaccine immunology : CVI · 2010Article
- The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections.Clinical and experimental immunology · 2009Article
- Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity.Clinical microbiology reviews · 2008Review
- Immunology of anaphylaxis: lessons from murine models.Current allergy and asthma reports · 2007Review
- Immune reactions and allergy in experimental anisakiasis.The Korean journal of parasitology · 2006Review
- Anaphylaxis Conundrum: A Trojan Horse Phenomenon.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of the singular hypersensitivity reactions to Anisakis simplex (A.s) proteins, may help us to undestand many of the unknown immune interactions between helmiths infections and allergy. We have developed a murine model of allergy to A. simplex, that mimics human A. simplex allergy to study the specific aspects of anaphylaxis induced by parasites. Male C3H/HeJ mice were intraperitoneally sensitized to A. simplex. Mice were then intravenous or orally challenged with A. simplex. Antigen-specific immunoglobulins, polyclonal IgE, anaphylactic symptoms, plasma histamine levels and cytokine profiles were determined. Comparative IgE immunoblot analyses were also performed. Specific IgE, IgG(1) and IgG(2a) were detected in sensitized mice since week 3. Polyclonal IgE raised and peaked with different kinetics. Intravenous A. simplex challenge produced anaphylaxis in mice, accompanied by plasma histamine release. Oral A. simplex challenge in similarly sensitized mice did not caused symptoms nor histamine release. Numerous A. simplex allergens were recognized by sensitized mouse sera, some of them similar to human serum. The A. simplex stimulated splenocytes released IL-10, IFN-gamma, IL-4, IL-13 and IL-5. We describe a new animal model of anaphylaxis. It exhibits characteristics of type I hypersensitivity reactions to Anisakis simplex similar to those observed in allergic humans. Different responses to i.v. or oral A. simplex challenges emerged, which did not reflect a window tolerization period. The cytokine profile developed (mixed Th(1)/Th(2) pattern) differed from the observed in classical models of anaphylaxis or allergy to food antigens. This model may permit to investigate the peculiar allergic reactions to parasitic proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.