ArticleBlood2006
High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Systematic transcriptome analysis reveals the function of alternative promoters in hematopoietic lineages.Stem cell reports · 2026Article
- Promoter switching in response to changing environment and elevated expression of protein-coding genes overlapping at their 5' ends.Scientific reports · 2021Article
- Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis.Molecular and cellular biology · 2021Article
- Genetics and Genomics Approaches for Diagnosis and Research Into Hereditary Anemias.Frontiers in physiology · 2020Review
- Article
- Article
- RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis.Frontiers in physiology · 2018Review
- Relatively frequent switching of transcription start sites during cerebellar development.BMC genomics · 2017Article
- Article
- Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation.Blood · 2014Article
- Developmental transcriptome analysis of human erythropoiesis.Human molecular genetics · 2014Article
- Expression of different functional isoforms in haematopoiesis.International journal of hematology · 2014Review
- Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom.PloS one · 2014Article
- Article
- Ferroportin and erythroid cells: an update.Advances in hematology · 2010Article
- Article
- Translational isoforms of FOG1 regulate GATA1-interacting complexes.The Journal of biological chemistry · 2009Article
- Identification, characterization and expression of novel Sex Hormone Binding Globulin alternative first exons in the human prostate.BMC molecular biology · 2009Article
- Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs.RNA (New York, N.Y.) · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The human genome uses alternative pre-mRNA splicing as an important mechanism to encode a complex proteome from a relatively small number of genes. An unknown number of these genes also possess multiple transcriptional promoters and alternative first exons that contribute another layer of complexity to gene expression mechanisms. Using a collection of more than 100 erythroid-expressed genes as a test group, we used genome browser tools and genetic databases to assess the frequency of alternative first exons in the genome. Remarkably, 35% of these erythroid genes show evidence of alternative first exons. The majority of the candidate first exons are situated upstream of the coding exons, whereas a few are located internally within the gene. Computational analyses predict transcriptional promoters closely associated with many of the candidate first exons, supporting their authenticity. Importantly, the frequent presence of consensus translation initiation sites among the alternative first exons suggests that many proteins have alternative N-terminal structures whose expression can be coupled to promoter choice. These findings indicate that alternative promoters and first exons are more widespread in the human genome than previously appreciated and that they may play a major role in regulating expression of selected protein isoforms in a tissue-specific manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.