ArticleJournal of neurophysiology2005
Signal propagation in oblique dendrites of CA1 pyramidal cells.
Article in Journal of neurophysiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 98 citations in OpenAlex.
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- Morpho-electric diversity of human hippocampal CA1 pyramidal neurons.Cell reports · 2024Article
- A realistic computational model for the formation of a Place Cell.Scientific reports · 2023Article
- Online conversion of reconstructed neural morphologies into standardized SWC format.Nature communications · 2023Article
- The impact of Hodgkin-Huxley models on dendritic research.The Journal of physiology · 2023Review
- Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive Head Impacts.Neuroinformatics · 2023Article
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- A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP.PLoS computational biology · 2019Article
- The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow.PLoS computational biology · 2018Article
- Feasibility and resolution limits of opto-magnetic imaging of neural network activity in brain slices using color centers in diamond.Scientific reports · 2018Article
- Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Post-Inhibitory Rebound Spikes in Rat Medial Entorhinal Layer II/III Principal Cells: In Vivo, In Vitro, and Computational Modeling Characterization.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Extending Integrate-and-Fire Model Neurons to Account for the Effects of Weak Electric Fields and Input Filtering Mediated by the Dendrite.PLoS computational biology · 2016Article
- Functionalized anatomical models for EM-neuron Interaction modeling.Physics in medicine and biology · 2016Article
Corrections and comments
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3 authors at 1 institution in 1 country.
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Abstract
The electrophysiological properties of the oblique branches of CA1 pyramidal neurons are largely unknown and very difficult to investigate experimentally. These relatively thin dendrites make up the majority of the apical tree surface area and constitute the main target of Schaffer collateral axons from CA3. Their electrogenic properties might have an important role in defining the computational functions of CA1 neurons. It is thus important to determine if and to what extent the back- and forward propagation of action potentials (AP) in these dendrites could be modulated by local properties such as morphology or active conductances. In the first detailed study of signal propagation in the full extent of CA1 oblique dendrites, we used 27 reconstructed three-dimensional morphologies and different distributions of the A-type K(+) conductance (K(A)), to investigate their electrophysiological properties by computational modeling. We found that the local K(A) distribution had a major role in modulating action potential back propagation, whereas the forward propagation of dendritic spikes originating in the obliques was mainly affected by local morphological properties. In both cases, signal processing in any given oblique was effectively independent of the rest of the neuron and, by and large, of the distance from the soma. Moreover, the density of K(A) in oblique dendrites affected spike conduction in the main shaft. Thus the anatomical variability of CA1 pyramidal cells and their local distribution of voltage-gated channels may suit a powerful functional compartmentalization of the apical tree.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.