ReviewThe international journal of biochemistry & cell biology2006
IgA1 protease.
Review in The international journal of biochemistry & cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- The protease code of the bacterial gut microbiota: ecological regulation, barrier disruption, and rewiring host defense and signaling.Gut microbes · 2026Review
- IgA binding characteristics of golden hamster and ferret Fcα receptors.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Examining the role of IgA in a persistent model of Staphylococcus aureus colonization.PLoS pathogens · 2026Article
- Structure of theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Protective Antimicrobial Effect of the Potential Vaccine Created on the Basis of the Structure of the IgA1 Protease fromVaccines · 2024Article
- An active learning card game to teach microbial pathogenesis to undergraduate biology majors.Journal of microbiology & biology education · 2024Article
- The immunoglobulin A isotype of the Arabian camel (Frontiers in immunology · 2023Article
- IgA-producing B cells in lung homeostasis and disease.Frontiers in immunology · 2023Review
- Secretory Cells Are the Primary Source of pIgR in Small Airways.American journal of respiratory cell and molecular biology · 2022Article
- Highly Similar Sequences of Mature IgA1 Proteases fromPathogens (Basel, Switzerland) · 2022Article
- Persistence of Anti SARS-CoV-2 Antibodies in Breast Milk from Infected and Vaccinated Women afterNutrients · 2022Article
- Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase.Advanced healthcare materials · 2022Article
- Comparative genome characterization of Leptospira interrogans from mild and severe leptospirosis patients.Genomics & informatics · 2021Article
- Serum IgA Fc effector functions in infectious disease and cancer.Immunology and cell biology · 2020Review
- The Versatility of Opportunistic Infections Caused byFrontiers in microbiology · 2020Article
- IgA: Structure, Function, and Developability.Antibodies (Basel, Switzerland) · 2019Review
- Streptococcus pneumoniae G5 domains bind different ligands.Protein science : a publication of the Protein Society · 2019Article
- Intranasal Immunization with the CommensalApplied and environmental microbiology · 2019Article
- Article
- Cloning and Expression of H. influenzae 49247 IgA Protease in E. coli.Molecular biotechnology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgA1 proteases are proteolytic enzymes that cleave specific peptide bonds in the human immunoglobulin A1 (IgA1) hinge region sequence. Several species of pathogenic bacteria secrete IgA1 proteases at mucosal sites of infection to destroy the structure and function of human IgA1 thereby eliminating an important aspect of host defence. IgA1 proteases are known as autotransporter proteins as their gene structure encodes the information to direct their own secretion out of the bacterial cell. The iga gene structure is also thought to contribute to the antigenic heterogeneity demonstrated by the IgA1 proteases during infections and the cleavage specificity of the IgA1 proteases for human IgA1. The IgA1 proteases have therefore been implicated as important virulence factors that contribute to bacterial infection and colonisation. The development of strategies to inactivate these IgA1 proteases has become the subject of recent research, as this has the potential to reduce bacterial colonisation at mucosal surfaces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.