ArticleJournal of clinical microbiology1992
Isotype antibody response in cows to Streptococcus agalactiae group B polysaccharide-ovalbumin conjugate.
Article in Journal of clinical microbiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- Surface Structures of Group BMicrobiology spectrum · 2019Review
- Immunization routes in cattle impact the levels and neutralizing capacity of antibodies induced against S. aureus immune evasion proteins.Veterinary research · 2015Article
- Identification and molecular characterization of a S. agalactiae strain lacking the capsular locus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Opsonization of Streptococcus agalactiae of bovine origin by complement and antibodies against group B polysaccharide.Infection and immunity · 1992Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult dairy cows were immunized with group B antigen (GBA) of Streptococcus agalactiae or GBA coupled to ovalbumin, both emulsified in incomplete Freund adjuvant, and their sera were examined by an enzyme-linked immunosorbent assay measuring bovine immunoglobulin isotypes (immunoglobulin G1 [IgG1], IgG2, and IgM) specific for GBA. All of the cows possessed naturally acquired antibodies against GBA, which implied that primary antibody responses could not be studied. At the highest dose tested (200 micrograms), free GBA elicited a slight increase in antibody titers only in the IgM isotype, to which most of the naturally acquired antibodies to GBA belonged. A second administration of antigen was not more effective. The conjugate was able to induce a strong humoral response against GBA, particularly in the IgG1 and IgG2 subisotypes, and a second injection of the conjugate induced a doubling of the peak antibody titers. Therefore, conjugation of GBA to a protein carrier markedly improved the antibody response, which showed the main characteristics of T-cell dependency. The opsonic activity of serum against an unencapsulated strain of S. agalactiae was reinforced by the immunization with the conjugate.
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