ArticlePLoS biology2005
Securin is not required for chromosomal stability in human cells.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- The Small but Versatile Cyclin-Dependent Kinase Subunit CKS: C. elegans CKS-1 Regulates Anaphase Onset and Is Required for Anaphase B During Oocyte Meiosis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Lamin B1-dependent regulation of human separase in mitosis.Nucleic acids research · 2026Article
- Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.The Journal of cell biology · 2026Article
- SGO2 does not play an essential role in separase inhibition during meiosis I in mouse oocytes.PLoS biology · 2025Article
- Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells.International journal of molecular sciences · 2023Article
- Review
- Structure and Function of the Separase-Securin Complex.Sub-cellular biochemistry · 2021Review
- Accumulation of Securin on Spindle During Female Meiosis I.Frontiers in cell and developmental biology · 2021Article
- Chromosomal Instability May Not Be a Predictor for Immune Checkpoint Inhibitors from a Comprehensive Bioinformatics Analysis.Life (Basel, Switzerland) · 2020Article
- Article
- Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.Nature communications · 2019Article
- Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.Nature communications · 2017Article
- The Role of Aneuploidy in Cancer Evolution.Cold Spring Harbor perspectives in medicine · 2017Review
- Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.The Journal of biological chemistry · 2015Article
- The sister bonding of duplicated chromosomes.Seminars in cell & developmental biology · 2011Review
- Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.Cell cycle (Georgetown, Tex.) · 2011Article
- Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.PloS one · 2011Article
- Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit.Molecular and cellular biology · 2011Article
- Article
- p53 suppresses structural chromosome instability after mitotic arrest in human cells.Oncogene · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest. Recently it has been reported that human cells without an hSecurin gene lose chromosomes at a high frequency. Here we show that, after hSecurin knockout through homologous recombination, chromosome losses are only a short, transient effect. After a few passages hSecurin(-/-) cells became chromosomally stable and executed mitoses normally. This was unexpected, as the securin loss resulted in a persisting reduction of the sister-separating protease separase and inefficient cleavage of the cohesin subunit Scc1. Our data demonstrate that securin is dispensable for chromosomal stability in human cells. We propose that human cells possess efficient mechanisms to compensate for the loss of genes involved in chromosome segregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.