ArticleJournal of neuro-oncology2006
Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival.
Article in Journal of neuro-oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
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- TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.Scientific reports · 2017Article
- Tissue thioredoxin reductase-1 expression in astrocytomas of different grades.Journal of neuro-oncology · 2015Article
- The peroxidase activity of mitochondrial superoxide dismutase.Free radical biology & medicine · 2013Article
- Silencing thioredoxin induces liver cancer cell senescence under hypoxia.Hepatology research : the official journal of the Japan Society of Hepatology · 2012Article
- Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis.Anti-cancer agents in medicinal chemistry · 2011Review
- The emerging role of the thioredoxin system in angiogenesis.Arteriosclerosis, thrombosis, and vascular biology · 2010Review
- Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.BMC cancer · 2010Article
- Total dietary antioxidant index and survival in patients with glioblastoma multiforme.Cancer causes & control : CCC · 2009Article
- Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas.Journal of neuro-oncology · 2008Article
- Carbonic anhydrase IX in oligodendroglial brain tumors.BMC cancer · 2008Article
- Glutathione peroxidase, glutathione reductase and protein oxidation in patients with glioblastoma multiforme and transitional meningioma.Journal of cancer research and clinical oncology · 2007Article
Corrections and comments
- Erratum issuedSally, Järvelä [corrected to Järvelä, Sally]; Helena, Bragge [corrected to Bragge, Helena]; Niina, Paunu [corrected to Paunu, Niina]; Timo, Järvelä [corrected to Järvelä, Timo]; Leo, Paljärvi [corrected to Paljärvi, Leo]; Hannu, Kalimo [corrected
Authors and funding
20 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose of the study was to investigate the relationship between antioxidant enzyme expression and clinicopathological features in oligodendroglial tumors. The expression of antioxidant enzymes and related proteins (AOEs), manganese superoxide dismutase (MnSOD), thioredoxin (Trx), thioredoxin reductase (TrxR) and gammaglutamylcysteine synthetase catalytic and regulatory subunits (GLCL-C and GLCL-R), was studied in 85 oligodendroglial tumors. The material included 71 primary (43 grade II and 28 grade III) and 14 recurrent (6 grade II and 8 grade III) tumors. Fifty-seven cases were pure oligodendrogliomas and 28 were mixed oligoastrocytomas. Immunoreactivity for MnSOD was found in 89%, Trx in 29%, TrxR in 76%, GLCL-C in 70% and GLCL-R in 68% of cases. Increased Trx expression was associated with higher tumor grade, cell proliferation and apoptosis (P=0.006, P=0.001 and P=0.003, Mann-Whitney test). Pure oligodendrogliomas showed more intense staining than oligoastrocytomas, especially for MnSOD (P=0.002, Mann-Whitney test). In the total series Trx was associated with poor prognosis in univariate survival analysis (P=0.0343, log-rank test) and furthermore in Cox multivariate analysis (P=0.009) along with age (P=0.002). The results suggest that the expression of Trx has a correlation to patient outcome and that there may be some association between AOEs, like MnSOD and Trx, and clinicopathological features of oligodendrogliomas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.