ArticleJournal of human genetics2006
Association of CD14 promoter polymorphisms and soluble CD14 levels in mite allergen sensitization of children in Taiwan.
Article in Journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis.BMC medical genetics · 2011Pooled it
- The -159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis.Immunogenetics · 2011Pooled it
- Asthma susceptible genes in Chinese population: a meta-analysis.Respiratory research · 2010Pooled it
- House dust mite allergy in Malaysia: review of research gaps in the current scenario and the way forward.Experimental & applied acarology · 2023Review
- A review of house dust mite allergy in India.Experimental & applied acarology · 2019Review
- CD14 as A Serum Immune Biomarker and Genetic Predisposition Factor for Allergic Rhinitis.Iranian journal of otorhinolaryngology · 2019Article
- Role of offending out-door aero-allergen and CD14 C(-159)T polymorphism in development and severity of asthma in a Kolkata patient population.African health sciences · 2017Article
- International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem.The World Allergy Organization journal · 2017Article
- Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.PloS one · 2016Article
- The effect of CD14 and TLR4 gene polymorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study.BMC pulmonary medicine · 2014Article
- Innate immune response of alveolar macrophage to house dust mite allergen is mediated through TLR2/-4 co-activation.PloS one · 2013Article
- Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.Journal of asthma and allergy · 2013Article
- CD14 gene variants and their importance for childhood croup, atopy, and asthma.Disease markers · 2013Article
- An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population.Journal of clinical immunology · 2009Article
- Soluble CD14: role in atopic disease and recurrent infections, including otitis media.Current allergy and asthma reports · 2007Review
- Soluble CD14 and CD83 from human neonatal antigen-presenting cells are inducible by commensal bacteria and suppress allergen-induced human neonatal Th2 differentiation.Infection and immunity · 2007Article
- PyPop update--a software pipeline for large-scale multilocus population genomics.Tissue antigens · 2007Article
- Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy.Journal of human genetics · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD14 is responsible for environmental lipopolysaccharide recognition and is a positional candidate gene for allergy. We hypothesized that genetic polymorphisms in the promoter region of the CD14 gene may be associated with Dermatophagoides pteronysinnus (Der p) allergen sensitization in children. Three single nucleotide polymorphisms (SNPs) of the CD14 promoter region, C(-159)T, A(-1,145)G, and G(-1,359)T were genotyped, and analyzed in 240 randomized case-control school-age children in Taiwan. Serum concentrations of IgE and soluble CD14 (sCD14) were also assayed. We found a significant inverse correlation of sCD14 and total serum IgE levels in our study population. Moreover, sCD14 binds Der p allergen in vitro in a dose-dependent manner. The distribution of three SNPs genotypes was similar in asthmatic children and the control group. However, there was a significant difference in the distribution of genotype CD14 G(-1,359)T, but not C(-159)T, between mite-sensitive and non-sensitive children. Haplotype analysis showed strong linkage disequilibrium among these three SNPs in the CD14 promoter region. Carriers of the CD14-159C/-1,145A/-1,359T haplotype had the highest IgE and lowest sCD14 levels as compared to other haplotypes. Our results support the hypothesis that CD14 gene variants may play an important role in influencing allergen sensitization of children in Taiwan.
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