ArticlePLoS genetics2005
Genome-wide association mapping in Arabidopsis identifies previously known flowering time and pathogen resistance genes.
Article in PLoS genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers.
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Who cites it
191 citing papers in PubMed.
- Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity.Plant, cell & environment · 2026Review
- From gene-for-gene to NLRome-for-effectorome: decoding the dynamic interplay between phytopathogenic effector networks and plant immune systems.FEMS microbiology reviews · 2026Review
- Metabolic plasticity and adaptive evolution inFrontiers in plant science · 2025Review
- GWAS for identification of genomic regions and candidate genes in vegetable crops.Functional & integrative genomics · 2024Review
- Genome-wide association study of fiber quality traits in US upland cotton (Gossypium hirsutum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- ZmADF5, a Maize Actin-Depolymerizing Factor Conferring Enhanced Drought Tolerance in Maize.Plants (Basel, Switzerland) · 2024Article
- Multi-environment GWAS identifies genomic regions underlying grain nutrient traits in foxtail millet (Setaria italica).Plant cell reports · 2023Article
- GWAS and Meta-QTL Analysis of Yield-Related Ear Traits in Maize.Plants (Basel, Switzerland) · 2023Article
- Exploring genetic diversity and ascertaining genetic loci associated with important fruit quality traits in apple (Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- The pan-genome and local adaptation of Arabidopsis thaliana.Nature communications · 2023Article
- Genome-wide association study of aphid abundance highlights a locus affecting plant growth and flowering inRoyal Society open science · 2023Article
- Review
- Genome-wide association study presents insights into the genetic architecture of drought tolerance in maize seedlings under field water-deficit conditions.Frontiers in plant science · 2023Article
- Functional Allele Validation by Gene Editing to Leverage the Wealth of Genetic Resources for Crop Improvement.International journal of molecular sciences · 2022Review
- Genome-Wide Association Study Identifies a Rice Panicle Blast Resistance Gene,International journal of molecular sciences · 2022Article
- Identification of Chilling Accumulation-Associated Genes for Litchi Flowering by Transcriptome-Based Genome-Wide Association Studies.Frontiers in plant science · 2022Article
- Preparation and Curation of Omics Data for Genome-Wide Association Studies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Evolutionary Ecology of Plant-Arthropod Interactions in Light of the "Omics" Sciences: A Broad Guide.Frontiers in plant science · 2022Review
- A Genome-Wide Association Study Dissects the Genetic Architecture of the Metaxylem Vessel Number in Maize Brace Roots.Frontiers in plant science · 2022Article
- Salinity tolerance mechanisms and their breeding implications.Journal, genetic engineering & biotechnology · 2021Review
131 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors.
Funding
Abstract
There is currently tremendous interest in the possibility of using genome-wide association mapping to identify genes responsible for natural variation, particularly for human disease susceptibility. The model plant Arabidopsis thaliana is in many ways an ideal candidate for such studies, because it is a highly selfing hermaphrodite. As a result, the species largely exists as a collection of naturally occurring inbred lines, or accessions, which can be genotyped once and phenotyped repeatedly. Furthermore, linkage disequilibrium in such a species will be much more extensive than in a comparable outcrossing species. We tested the feasibility of genome-wide association mapping in A. thaliana by searching for associations with flowering time and pathogen resistance in a sample of 95 accessions for which genome-wide polymorphism data were available. In spite of an extremely high rate of false positives due to population structure, we were able to identify known major genes for all phenotypes tested, thus demonstrating the potential of genome-wide association mapping in A. thaliana and other species with similar patterns of variation. The rate of false positives differed strongly between traits, with more clinal traits showing the highest rate. However, the false positive rates were always substantial regardless of the trait, highlighting the necessity of an appropriate genomic control in association studies.
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