ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 78 citations in OpenAlex.
- Inhibition of Gap Junction Formation Prior to Implantation of Bone Marrow-Derived Mesenchymal Cells Improves Function in the Ischemic Myocardium.International journal of molecular sciences · 2023Article
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Review
- Mechanisms of Spontaneous Electrical Activity in the Developing Cerebral Cortex-Mouse Subplate Zone.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Live imaging of developing mouse retinal slices.Neural development · 2018Article
- ATP-induced CaCellular and molecular life sciences : CMLS · 2017Review
- Live-cell imaging: new avenues to investigate retinal regeneration.Neural regeneration research · 2017Review
- Culture of Adult Transgenic Zebrafish Retinal Explants for Live-cell Imaging by Multiphoton Microscopy.Journal of visualized experiments : JoVE · 2017Article
- Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?Cellular and molecular life sciences : CMLS · 2015Review
- High glucose alters Cx43 expression and gap junction intercellular communication in retinal Müller cells: promotes Müller cell and pericyte apoptosis.Investigative ophthalmology & visual science · 2014Article
- Spontaneous Network Activity and Synaptic Development.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Effects of vitamin D receptor knockout on cornea epithelium gap junctions.Investigative ophthalmology & visual science · 2014Article
- Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina.Stem cells and development · 2014Article
- Tissue plasminogen activator contributes to alterations of neuronal migration and activity-dependent responses in fragile X mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Developmental and functional expression of miRNA-stability related genes in the nervous system.PloS one · 2013Article
- Interkinetic nuclear migration: beyond a hallmark of neurogenesis.Cellular and molecular life sciences : CMLS · 2012Review
- Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Interkinetic nuclear movement in the ventricular zone of the cortex.Journal of molecular neuroscience : MN · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G(1) and G(2) of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic nuclear movement. Because division can only occur at the ventricular surface, factors that affect the speed of nuclear movement could modulate the duration of the cell cycle. Gap-junctional coupling and gap junction-dependent Ca(2+) activity are common features of proliferating cells in the immature nervous system. Furthermore, both gap-junctional coupling and changes in [Ca(2+)](i) have been shown to be positively correlated with the migration of a number of immature cell types. Using time-lapse confocal microscopy, we describe the nature and rate of progenitor cell interkinetic nuclear movement. We show that nuclear movement is usually, but not always, associated with Ca(2+) transients and that buffering of these transients with BAPTA slows movement. Furthermore, we show for the first time that gap-junctional communication is an important requirement for the maintenance of normal nuclear movement in retinal progenitor cells. Conventional blockers of gap junctions and transfection of cells with dominant-negative constructs of connexin 43 (Cx43) and Cx43-specific antisense oligodeoxynucleotides (asODNs) all act to slow interkinetic nuclear movement. The gap junction mimetic peptide Gap26 also acts to slow movement, an effect that we show may be attributable to the blockade of gap junction hemichannels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.