ArticleJournal of bacteriology2005
A degenerate type III secretion system from septicemic Escherichia coli contributes to pathogenesis.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Escherichia coli Type III Secretion System 2 Is Associated With Patient Mortality in Bloodstream Infections.The Journal of infectious diseases · 2025Article
- Sublethal concentrations of antibiotics enhance transmission of antibiotic resistance genes in environmentalFrontiers in microbiology · 2025Article
- Effects of Bacillus in Pectobacterium quorum quenching: A survey of two different acyl-homoserine lactonases.Folia microbiologica · 2024Article
- Genetic distribution, characterization, and function ofiScience · 2024Review
- Global Genomic Epidemiology ofMicroorganisms · 2022Article
- An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstreamMicrobial genomics · 2022Article
- Enteroinvasive Escherichia coli O96:H19 is an Emergent Biofilm-Forming Pathogen.Journal of bacteriology · 2022Article
- Transcription Regulator YgeK Affects the Virulence of Avian PathogenicAnimals : an open access journal from MDPI · 2021Article
- Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.BMC veterinary research · 2020Article
- A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage.Scientific reports · 2020Article
- Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity.Microorganisms · 2020Review
- Characterization and potential mechanisms of highly antibiotic tolerant VBNC Escherichia coli induced by low level chlorination.Scientific reports · 2020Article
- Article
- Genome analyses ofGut pathogens · 2018Article
- Escherichia coli type III secretion system 2 (ETT2) is widely distributed in avian pathogenic Escherichia coli isolates from Eastern China.Epidemiology and infection · 2016Article
- The Type Three Secretion System 2-Encoded Regulator EtrB Modulates Enterohemorrhagic Escherichia coli Virulence Gene Expression.Infection and immunity · 2016Article
- Human Meningitis-Associated Escherichia coli.EcoSal Plus · 2016Review
- Escherichia coli Type III Secretion System 2 ATPase EivC Is Involved in the Motility and Virulence of Avian Pathogenic Escherichia coli.Frontiers in microbiology · 2016Article
- Defining the Genome Features of Escherichia albertii, an Emerging Enteropathogen Closely Related to Escherichia coli.Genome biology and evolution · 2015Article
- Genomic avenue to avian colisepticemia.mBio · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type III secretion system (T3SS) is an important virulence factor used by several gram-negative bacteria to deliver effector proteins which subvert host cellular processes. Enterohemorrhagic Escherichia coli O157 has a well-defined T3SS involved in attachment and effacement (ETT1) and critical for virulence. A gene cluster potentially encoding an additional T3SS (ETT2), which resembles the SPI-1 system in Salmonella enterica, was found in its genome sequence. The ETT2 gene cluster has since been found in many E. coli strains, but its in vivo role is not known. Many of the ETT2 gene clusters carry mutations and deletions, raising the possibility that they are not functional. Here we show the existence in septicemic E. coli strains of an ETT2 gene cluster, ETT2(sepsis), which, although degenerate, contributes to pathogenesis. ETT2(sepsis) has several premature stop codons and a large (5 kb) deletion, which is conserved in 11 E. coli strains from cases of septicemia and newborn meningitis. A null mutant constructed to remove genes coding for the putative inner membrane ring of the secretion complex exhibited significantly reduced virulence. These results are the first demonstration of the importance of ETT2 for pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.