ArticleJournal of bacteriology2005
Vibrio cholerae ToxT independently activates the divergently transcribed aldA and tagA genes.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- A comparative study of low-pH tolerance and chitinase activity between toxigenic and non-toxigenic strains ofJournal of biosciences · 2026Article
- Article
- H-NS and ToxT Inversely Control Cholera Toxin Production by Binding to Overlapping DNA Sequences.Journal of bacteriology · 2021Article
- Article
- Structural basis for virulence regulation inCommunications biology · 2019Article
- Prediction of bacterial small RNAs in the RsmA (CsrA) and ToxT pathways: a machine learning approach.BMC genomics · 2017Article
- Transcriptional Repression of the VC2105 Protein by Vibrio FadR Suggests that It Is a New Auxiliary Member of the fad Regulon.Applied and environmental microbiology · 2016Article
- Mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile.Journal of bacteriology · 2015Article
- Evolutionary adaptation of an AraC-like regulatory protein in Citrobacter rodentium and Escherichia species.Infection and immunity · 2015Article
- A small unstructured region in Vibrio cholerae ToxT mediates the response to positive and negative effectors and ToxT proteolysis.Journal of bacteriology · 2015Article
- Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters.Journal of bacteriology · 2014Article
- Zebrafish as a natural host model for Vibrio cholerae colonization and transmission.Applied and environmental microbiology · 2014Article
- Determination of ctxAB expression in Vibrio cholerae Classical and El Tor strains using Real-Time PCR.International journal of molecular and cellular medicine · 2013Article
- Vibrio cholerae as a predator: lessons from evolutionary principles.Frontiers in microbiology · 2013Article
- Identification and characterization of the functional toxboxes in the Vibrio cholerae cholera toxin promoter.Journal of bacteriology · 2012Article
- Article
- N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids.The Journal of biological chemistry · 2011Article
- The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis.Molecular microbiology · 2011Article
- TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins.Microbiology (Reading, England) · 2011Article
- The complexity of ToxT-dependent transcription in Vibrio cholerae.The Indian journal of medical research · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The Vibrio cholerae ToxT regulon includes the genes encoding cholera toxin (CT) and the toxin-coregulated pilus (TCP), which are the major virulence factors required for causing cholera disease and colonizing the upper small intestine of the host, respectively. The genes encoding CT, ctxAB, and the genes encoding the components of the TCP, tcpA to tcpJ, are organized within operons, upstream of which are DNA binding sites for the transcriptional activator ToxT. ToxT is a member of the large AraC/XylS family of transcriptional regulators and also activates transcription of five other genes whose roles in V. cholerae pathogenesis, if any, are poorly understood. acfA and acfD are divergently transcribed genes required for efficient colonization of the intestine. Transcriptional activation of acfA and acfD requires a pair of central ToxT binding sites in an inverted-repeat configuration for ToxT-directed transcription of both genes. tcpI has an unknown role in pathogenesis. aldA and tagA are divergently transcribed genes that also have unknown roles in pathogenesis. In this study, we map the aldA and tagA promoters and identify the ToxT binding sites upstream of each gene. Our results suggest that two ToxT binding sites in an inverted-repeat configuration are required for ToxT-directed transcription of tagA and that a single ToxT binding site is required for ToxT-directed transcription of aldA. Furthermore, to direct transcription of tagA and aldA, ToxT uses independent binding regions upstream of each gene, in contrast to what we previously found for the divergently transcribed acfA and acfD genes, which share ToxT binding sites between the two genes.
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