ArticleJournal of molecular biology2005
Correlation of gene and protein structures in the FXYD family proteins.
Article in Journal of molecular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.Biochimica et biophysica acta · 2015Article
- Protein structure validation and identification from unassigned residual dipolar coupling data using 2D-PDPA.Molecules (Basel, Switzerland) · 2013Article
- Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis.The American journal of pathology · 2009Article
- Effects of PKA phosphorylation on the conformation of the Na,K-ATPase regulatory protein FXYD1.Biochimica et biophysica acta · 2009Article
- Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets.Pharmacological reviews · 2009Review
- Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling.Biomarker insights · 2007Article
- Membrane orientation of the Na,K-ATPase regulatory membrane protein CHIF determined by solid-state NMR.Magnetic resonance in chemistry : MRC · 2007Article
- Structures of the FXYD regulatory proteins in lipid micelles and membranes.Journal of bioenergetics and biomembranes · 2007Review
- Structural similarity of a membrane protein in micelles and membranes.Journal of the American Chemical Society · 2007Article
- Structure of the Na,K-ATPase regulatory protein FXYD1 in micelles.Biochemistry · 2007Article
- NMR of membrane proteins in micelles and bilayers: the FXYD family proteins.Methods (San Diego, Calif.) · 2007Article
- Nuclear magnetic resonance structural studies of membrane proteins in micelles and bilayers.Methods in molecular biology (Clifton, N.J.) · 2007Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The FXYD family proteins are auxiliary subunits of the Na,K-ATPase, expressed primarily in tissues that specialize in fluid or solute transport, or that are electrically excitable. These proteins range in size from about 60 to 160 amino acid residues, and share a core homology of 35 amino acid residues in and around a single transmembrane segment. Despite their relatively small sizes, they are all encoded by genes with six to nine small exons. We show that the helical secondary structures of three FXYD family members, FXYD1, FXYD3, and FXYD4, determined in micelles by NMR spectroscopy, reflect the structures of their corresponding genes. The coincidence of helical regions, and connecting segments, with the positions of intron-exon junctions in the genes, support the hypothesis that the FXYD proteins may have been assembled from discrete structural modules through exon shuffling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.