ArticleBMC infectious diseases2005
Mechanisms of escape phenomenon of spinal cord and brainstem in human rabies.
Article in BMC infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Enhanced rabies surveillance in roadkill specimens by real-time RT-PCR.PLoS neglected tropical diseases · 2025Article
- Detection of Apparent Early Rabies Infection by LN34 Pan-Lyssavirus Real-Time RT-PCR Assay in Pennsylvania.Viruses · 2022Article
- Transcriptome Profile During Rabies Virus Infection: Identification of Human CXCL16 as a Potential New Viral Target.Frontiers in cellular and infection microbiology · 2021Article
- Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons.Acta neuropathologica communications · 2020Article
- Impact of caspase-1/11, -3, -7, or IL-1Cell death discovery · 2017Article
- Update on rabies.Research and reports in tropical medicine · 2011Review
- Role of apoptosis in rabies viral encephalitis: a comparative study in mice, canine, and human brain with a review of literature.Pathology research international · 2011Article
- Article
- Neuronal apoptosis does not play an important role in human rabies encephalitis.Journal of neurovirology · 2008Article
- Furious and paralytic rabies of canine origin: neuroimaging with virological and cytokine studies.Journal of neurovirology · 2008Article
- Proteomic profiling reveals that rabies virus infection results in differential expression of host proteins involved in ion homeostasis and synaptic physiology in the central nervous system.Journal of neurovirology · 2007Article
- Rabies.Current neurology and neuroscience reports · 2006Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRabies virus preferentially involves brainstem, thalamus and spinal cord in human furious and paralytic rabies beginning in the early stage of illness. Nevertheless, rabies patient remains alert until the pre-terminal phase. Weakness of extremities develops only when furious rabies patient becomes comatose; whereas peripheral nerve dysfunction is responsible for weakness in paralytic rabies.
methodsEvidence of apoptosis and mitochondrial outer membrane permeabilization in brain and spinal cord of 10 rabies patients was examined and these findings were correlated with the presence of rabies virus antigen.
resultsAlthough apoptosis was evident in most of the regions, cytochrome c leakage was relatively absent in spinal cord of nearly all patients despite the abundant presence of rabies virus antigen. Such finding was also noted in brainstem of 5 patients.
conclusionCell death in human rabies may be delayed in spinal cord and the reticular activating system, such as brainstem, thus explaining absence of weakness due to spinal cord dysfunction and preservation of consciousness.
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