ReviewOncogene2005
Class reunion: PTEN joins the nuclear crew.
Review in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 104 citations in OpenAlex.
- Integrative Bioinformatics Analysis Reveals Potential Target Genes and PTEN Signaling in Breast Cancer and Effect of Zingiber officinale (Ginger) and Allium sativum (Garlic) extract on It.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Autophagy as a modulator of cell death machinery.Cell death & disease · 2020Review
- Nuclear phosphoinositide regulation of chromatin.Journal of cellular physiology · 2018Review
- Oxymatrine suppresses the growth and invasion of MG63 cells by up-regulating PTEN and promoting its nuclear translocation.Oncotarget · 2017Article
- Inhibition of miR301 enhances Akt-mediated cell proliferation by accumulation of PTEN in nucleus and its effects on cell-cycle regulatory proteins.Oncotarget · 2016Article
- Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?Molecular neurobiology · 2015Review
- The Optimization of Soluble PTEN Expression in Escherichia coli.The open biochemistry journal · 2015Article
- The pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noise.PLoS computational biology · 2014Article
- PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN.The Journal of clinical endocrinology and metabolism · 2014Article
- Differential localisation of PARP-1 N-terminal fragment in PARP-1(+/+) and PARP-1(-/-) murine cells.Molecules and cells · 2014Article
- PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress.Antioxidants & redox signaling · 2014Article
- The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Frontiers in oncology · 2014Review
- Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.Frontiers in molecular neuroscience · 2014Review
- PTEN, Longevity and Age-Related Diseases.Biomedicines · 2013Review
- Where is mTOR and what is it doing there?The Journal of cell biology · 2013Review
- Article
- mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.BMC cell biology · 2013Article
- PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.The Journal of clinical endocrinology and metabolism · 2012Article
- PTEN in DNA damage repair.Cancer letters · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.