ArticleOncogene2006
Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
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- Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.British journal of cancer · 2023Article
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- Prune homolog 2 with BCH domain (PRUNE2) gene expression is associated with feed efficiency-related traits in Nelore steers.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- ERK Inhibitor Ulixertinib Inhibits High-Risk Neuroblastoma Growth In Vitro and In Vivo.Cancers · 2022Article
- PRUNE2 inhibits progression of colorectal cancerExperimental and therapeutic medicine · 2022Article
- Genomic Tools for the Conservation and Genetic Improvement of a Highly Fragmented Breed-The Ramo Grande Cattle from the Azores.Animals : an open access journal from MDPI · 2020Article
- Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.BMC cancer · 2019Article
- OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma.Frontiers in oncology · 2019Article
- Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma.Genes, chromosomes & cancer · 2018Article
- (Pro)renin receptor (ATP6AP2) depletion arrests As4.1 cells in the G0/G1 phase thereby increasing formation of primary cilia.Journal of cellular and molecular medicine · 2017Article
- The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.Cancer research · 2015Article
- PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis.Cell death & disease · 2015Article
- High expression of MACC1 predicts poor prognosis in patients with osteosarcoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The prognostic role of PRUNE2 in leiomyosarcoma.Chinese journal of cancer · 2013Article
- Apoptotic cell death in neuroblastoma.Cells · 2013Article
- Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma.Cancer science · 2013Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differential screening of the genes obtained from cDNA libraries of primary neuroblastomas (NBLs) between the favorable and unfavorable subsets has identified a novel gene BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1). Its 350 kDa protein product possessed a Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 (BNIP2) and Cdc42GAP homology domain in the COOH-terminus in addition to P-loop and a coiled-coil region near the NH2-terminus. High levels of BMCC1 expression were detected in the human nervous system as well as spinal cord, brain and dorsal root ganglion in mouse embryo. The immunohistochemical study revealed that BMCC1 was positively stained in the cytoplasm of favorable NBL cells but not in unfavorable ones with MYCN amplification. The quantitative real-time reverse transcription-PCR using 98 primary NBLs showed that high expression of BMCC1 was a significant indicator of favorable NBL. In primary culture of newborn mice superior cervical ganglion (SCG) neurons, mBMCC1 expression was downregulated after nerve growth factor (NGF)-induced differentiation, and upregulated during the NGF-depletion-induced apoptosis. Furthermore, the proapoptotic function of BMCC1 was also suggested by increased expression in CHP134 NBL cells undergoing apoptosis after treatment with retinoic acid, and by an enhanced apoptosis after depletion of NGF in the SCG neurons obtained from newborn mice transgenic with BMCC1 in primary culture. Thus, BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
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