ArticleMolecular vision2005
Genetic networks controlling retinal injury.
Article in Molecular vision, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- AMD Genetics in India: The Missing Links.Frontiers in aging neuroscience · 2016Review
- Networks modulating the retinal response to injury: insights from microarrays, expression genetics, and bioinformatics.Advances in experimental medicine and biology · 2012Review
- Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network.Molecular vision · 2011Article
- Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush.BMC neuroscience · 2009Article
- Genomic loci modulating the retinal transcriptome in wound healing.Gene regulation and systems biology · 2008Article
- Hypoxia-regulated components of the U4/U6.U5 tri-small nuclear riboprotein complex: possible role in autosomal dominant retinitis pigmentosa.Molecular vision · 2008Article
- Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains.Molecular vision · 2007Article
- Sharing and reusing gene expression profiling data in neuroscience.Neuroinformatics · 2007Review
- Regulation of gene expression in the mammalian eye and its relevance to eye disease.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe present study defines genomic loci underlying coordinate changes in gene expression following retinal injury.
methodsA group of acute phase genes expressed in diverse nervous system tissues was defined by combining microarray results from injury studies from rat retina, brain, and spinal cord. Genomic loci regulating the brain expression of acute phase genes were identified using a panel of BXD recombinant inbred (RI) mouse strains. Candidate upstream regulators within a locus were defined using single nucleotide polymorphism databases and promoter motif databases.
resultsThe acute phase response of rat retina, brain, and spinal cord was dominated by transcription factors. Three genomic loci control transcript expression of acute phase genes in brains of BXD RI mouse strains. One locus was identified on chromosome 12 and was highly correlated with the expression of classic acute phase genes. Within the locus we identified the inhibitor of DNA binding 2 (Id2) as a candidate upstream regulator. Id2 was upregulated as an acute phase transcript in injury models of rat retina, brain, and spinal cord.
conclusionsWe defined a group of transcriptional changes associated with the retinal acute injury response. Using genetic linkage analysis of natural transcript variation, we identified regulatory loci and candidate regulators that control transcript levels of acute phase genes.
Indexed as
Identifiers
16288200PMC2814057W1551715098What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.