ArticleThe EMBO journal1992
A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
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- Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.Genes & development · 2019Article
- IL-7-induced phosphorylation of the adaptor Crk-like and other targets.Cellular signalling · 2018Article
- Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Myoinformatics report: myosin regulatory light chain paralogs in the human genome.Journal of muscle research and cell motility · 2006Article
- Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.Molecular and cellular biology · 2000Article
- Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny.The Journal of experimental medicine · 1994Article
- Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.The Journal of experimental medicine · 1994Article
- A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.Molecular and cellular biology · 1993Article
- The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.The Journal of experimental medicine · 1993Article
- B cell development in mice that lack one or both immunoglobulin kappa light chain genes.The EMBO journal · 1993Article
- Comparative analysis of dorsal and tail skin reveals region-dependent heterogeneity in axolotl skin regeneration.Cell transplantationArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
We describe a novel regulatory myosin light chain gene (termed precursor lymphocyte-specific regulatory light chain or PLRLC) that is expressed specifically in precursor B and T lymphocytes. PLRLC is the first example of a regulatory myosin light chain gene which displays specific expression in non-muscle cells. PLRLC is expressed in adult bone marrow derived normal and transformed pre-B cells; in the former, PLRLC expression levels are induced by the pre-B cell specific growth factor interleukin-7 (IL-7). PLRLC is not expressed in either transformed pre-B cells derived from fetal liver or in normal fetal liver pre-B clones grown in the presence of IL-7. Therefore this gene provides the first marker that clearly distinguishes these two pre-B subsets. Finally, several of the different PLRLC transcripts potentially encode regulatory myosin light chains with unique structural features. The unique distribution, regulation and structural features of the PLRLC gene products suggest an important role for PLRLC during lymphocyte development.
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