ArticleThe EMBO journal1992
Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.Molecular and cellular biology · 2007Article
- A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.Immunity · 2005Article
- B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.Molecular and cellular biology · 2000Article
- Receptor selection in B and T lymphocytes.Annual review of immunology · 2000Review
- Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.The Journal of experimental medicine · 1999Article
- RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.The Journal of experimental medicine · 1998Article
- Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development.The Journal of experimental medicine · 1997Article
- Further investigation of the light chain shifting phenomenon: light chain replacement through secondary rearrangement induced by lectin stimulation in the hybridoma cell line HB4C5.Cytotechnology · 1997Article
- Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2.Journal of virology · 1995Article
- Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors.The Journal of experimental medicine · 1995Article
- The recombination activation gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis.Immunogenetics · 1995Article
- Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.The EMBO journal · 1994Article
- Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.The Journal of experimental medicine · 1993Article
- The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.The Journal of experimental medicine · 1993Article
- Receptor editing in self-reactive bone marrow B cells.The Journal of experimental medicine · 1993Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Transgenic mice carrying either the c-myc or N-myc oncogene deregulated by the immunoglobulin heavy chain enhancer element (E mu) develop both pre-B and B cell lymphomas (E mu-c-myc and E mu-N-myc lymphomas). We report here that B cell lines derived from these tumors, as well as a line derived from v-myc retroviral transformation, simultaneously express surface immunoglobulin (a hallmark of mature B cells) as well as a common subset of genes normally restricted to the pre-B stage of development-including the recombinase activating genes RAG-1 and RAG-2. Continued RAG-1 and RAG-2 expression in these lines is associated with VDJ recombinase activity detected with a VDJ recombination substrate. Cross-linking of the surface immunoglobulin on these lines with an anti-mu antibody leads to rapid, specific and reversible down-regulation of RAG-1 and RAG-2 gene expression. We also find that a small but significant percentage of normal surface immunoglobulin bearing bone marrow B cells express the RAG-1 gene. These findings are discussed in the context of their possible implications for the control of specific gene expression during the pre-B to B cell transition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.