ArticleThe EMBO journal1992
Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 105 citations in OpenAlex.
- Article
- Predicting Key Genes and Therapeutic Molecular Modelling to Explain the Association betweenInternational journal of molecular sciences · 2023Article
- Id(entifying) the inhibitor of DNA binding 3 in the brain of Nothobranchius furzeri upon aging.Journal of anatomy · 2021Article
- NRF3 suppresses breast cancer cell metastasis and cell proliferation and is a favorable predictor of survival in breast cancer.OncoTargets and therapy · 2019Article
- Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer.Translational oncology · 2018Article
- Inhibitor of DNA binding 3 reverses cisplatin resistance in human lung adenocarcinoma cells by regulating the PI3K/Akt pathway.Oncology letters · 2018Article
- The Id-protein family in developmental and cancer-associated pathways.Cell communication and signaling : CCS · 2017Review
- Id2a is required for hepatic outgrowth during liver development in zebrafish.Mechanisms of development · 2015Article
- Id3 induces an Elk-1-caspase-8-dependent apoptotic pathway in squamous carcinoma cells.Cancer medicine · 2015Article
- Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs.Development (Cambridge, England) · 2015Article
- Expression pattern of id proteins in medulloblastoma.Pathology oncology research : POR · 2013Article
- Susceptibility of hepatoma-derived cells to histone deacetylase inhibitors is associated with ID2 expression.International journal of oncology · 2013Article
- Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.PloS one · 2011Article
- Helix-loop-helix proteins in mammary gland development and breast cancer.Journal of mammary gland biology and neoplasia · 2003Review
- Inhibitors of DNA binding in neural cell proliferation and differentiation.Neurochemical research · 2003Review
- Id proteins in cell cycle control and cellular senescence.Oncogene · 2001Review
- Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.Molecular and cellular biology · 1999Article
- Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors.Molecular and cellular biology · 1998Article
- Localisation of a gene causing endocrine neoplasia to a 4 cM region on chromosome 1p35-p36.Journal of medical genetics · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a novel human gene encoding a helix-loop-helix (HLH) protein by molecularly cloning chromosome 1p36-specific CpG islands. The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12. Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins. Heir-1 does not encode a basic DNA binding domain as found in basic HLH proteins. The gene is expressed specifically at high abundance in adult lung, kidney and adrenal medulla, but not in adult brain. Despite prominent heir-1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 out of 12 neuroblastoma-derived cell lines revealed very low levels of heir-1 mRNA. Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc. Mutually exclusive expression of both genes was also found by in situ hybridization in developing mouse tissues, particularly in the forebrain neuroectoderm. We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.