Evidence map›Paper›PMID 16284779›Full record

ArticleParasitology research2006

Prevalence and genetic diversity of Entamoeba histolytica in an institution for the mentally retarded in the Philippines.

Windell L Rivera, Sherwin R Santos, Hiroji Kanbara

Abstract read
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In one paragraph

Article in Parasitology research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Development of a salivary IgA detection method for accurate diagnosis of amebiasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Evolutionary genomics and population structure of Entamoeba histolytica.Computational and structural biotechnology journal · 2014
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Molecular epidemiology of amebiasis.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Windell L RiveraInstitute of Biology, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines. windell.rivera@up.edu.ph
Sherwin R Santos
Hiroji Kanbara

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A total of 113 mentally retarded patients residing in a mental institution in Metropolitan Manila, Philippines, were screened for the presence of Entamoeba histolytica based on microscopy and polymerase chain reaction (PCR). Anti-E. histolytica antibodies were also screened in 97 serum samples collected using immunofluorescence antibody (IFA) test. Parasitological examination showed E. histolytica/Entamoeba dispar in 43 cases (38.05%), while PCR detected 74 cases (65.48%) positive for E. histolytica and 6 cases (5.30%) positive for E. dispar. Interestingly, these 6 samples were coinfected with E. histolytica. IFA test revealed that 80.41% (78/97) of the respondents possessed significant antibody titers for intestinal infection of E. histolytica. Of this number, there were 5 patients negative in IFA test but positive in PCR. The genetic diversity of E. histolytica isolates was also investigated by analyzing polymorphism in the serine-rich gene by nested PCR on DNA directly extracted from stool specimens. A combination of the nested PCR results and the AluI digestion of the PCR products examined yielded six distinct DNA banding patterns among the 74 stool isolates. An apparent clustering of E. histolytica strains was observed in patients living in different residential cottages of the institution. These results indicate the high prevalence of E. histolytica in an institution for the mentally retarded in the Philippines.

Indexed as

Genetic VariationHealth FacilitiesPersons with Intellectual DisabilitiesAnimalsAntibodies, ProtozoanDNA, ProtozoanEntamoebaEntamoeba histolyticaEntamoebiasisFecesHumansPhilippinesPolymerase Chain ReactionPrevalenceAntibodies, ProtozoanDNA, Protozoan

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.