Trial reportSkeletal radiology2006
MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome.
Trial report in Skeletal radiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- We do not have evidence based methods for the treatment of cartilage defects in the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Pooled it
- Matrix-induced autologous chondrocyte implantation of the knee: mid-term and long-term follow-up by MR arthrography.Skeletal radiology · 2011Trial
- Article
- Subchondral bone: An emerging target for the treatment of articular surface lesions of the knee.Journal of experimental orthopaedics · 2024Review
- Correlation of Postoperative Imaging With MRI and Clinical Outcome After Cartilage Repair of the Ankle: A Systematic Review and Meta-analysis.Foot & ankle orthopaedics · 2022Article
- Bifunctional Labeling of Rabbit Mesenchymal Stem Cells for MR Imaging and Fluorescence Microscopy.Molecular imaging and biology · 2020Article
- Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy.Bioengineering (Basel, Switzerland) · 2019Review
- Correlation of MRI Appearance of Autologous Chondrocyte Implantation in the Ankle with Clinical Outcome.Cartilage · 2018Article
- Bone marrow lesions and subchondral bone pathology of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Review
- Aetiology and pathogenesis of bone marrow lesions and osteonecrosis of the knee.EFORT open reviews · 2016Article
- Bone marrow edema and results after cartilage repair.Annals of translational medicine · 2015Article
- Is the clinical outcome after cartilage treatment affected by subchondral bone edema?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Cell-based approaches to joint surface repair: a research perspective.Osteoarthritis and cartilage · 2013Review
- Article
- Article
- Clinical application of scaffolds for cartilage tissue engineering.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2009Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo relate the magnetic resonance imaging (MRI) appearance of autologous chondrocyte implantation (ACI) in the knee in the 1st postoperative year with other knee features on MRI and with clinical outcome. DESIGN AND
methodsForty-nine examinations were performed in 49 patients at 1 year after ACI in the knee. Forty-one preoperative magnetic resonance (MR) examinations were also available. The grafts were assessed for smoothness, thickness in comparison with that of adjacent cartilage, signal intensity, integration to underlying bone and adjacent cartilage, and congruity of subchondral bone. Presence of overgrowth and bone marrow appearance beneath the graft were also assessed. Presence of osteophyte formation, further cartilage defects, appearance of the cruciate ligaments and the menisci were also recorded. An overall graft score was constructed, using the graft appearances. This was correlated with the knee features and the Lysholm score, a clinical self-assessment score. The data were analysed by a Kruskal-Wallis H test followed by a Mann-Whitney U test with Bonferroni correction as post-hoc test.
resultsOf 49 grafts, 32 (65%) demonstrated complete defect filling 1 year postoperatively. General overgrowth was seen in eight grafts (16%), and partial overgrowth in 13 grafts (26%). Bone marrow change underneath the graft was seen; oedema was seen in 23 grafts (47%), cysts in six grafts (12%) and sclerosis in two grafts (4%). Mean graft score was 8.7 (of maximal 12) (95% CI 8.0-9.5). Knees without osteophyte formation or additional other cartilage defects (other than the graft site) had a significantly higher graft score than knees with multiple osteophytes (P=0.0057) or multiple further cartilage defects (P=0.014). At 1 year follow-up improvement in the clinical scores was not significantly different for any subgroup. Knees with a graft score of 8 points or greater had a better improvement of the clinical score than those of 7 points or fewer.
conclusionsAt 1 year follow-up after ACI, higher graft scores are associated with an overall better preserved knee joint. ACI improves the clinical outcome, but there is no statistically significant correlation of graft score and clinical outcome.
Indexed as
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16284767What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.