ArticleDiabetologia2006
Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects.Journal of human hypertension · 2017Pooled it
- Pooled it
- Associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors in Korean obese women.Journal of endocrinological investigation · 2014Trial
- A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults.Gastroenterology · 2008Trial
- The association between the GNB3 rs5443 C/C genotype and obesity phenotypes in Taiwanese individuals.BioMedicine · 2026Article
- Genetic variants of accessory proteins and G proteins in human genetic disease.Critical reviews in clinical laboratory sciences · 2025Review
- Metabolic syndrome and underlying genetic determinants-A systematic review.Journal of diabetes and metabolic disorders · 2022Review
- Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus.Frontiers in physiology · 2022Review
- A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.The pharmacogenomics journal · 2017Article
- Role of GNB3, NET, KCNJ11, TCF7L2 and GRL genes single nucleotide polymorphism in the risk prediction of type 2 diabetes mellitus.3 Biotech · 2016Review
- Association of the G-protein β3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study.Journal of human hypertension · 2013Article
- Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population.Genes & nutrition · 2013Article
- Genetic variation in female BMI increases with number of children born but failure to replicate association between GNbeta3 variants and increased BMI in parous females.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2009Article
- APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.Archives of medical research · 2007Article
- Studies of the associations between functional beta2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects.Diabetologia · 2007Article
- Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.Diabetologia · 2006Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome. MATERIALS AND
methodsThe GNB3 825C>T polymorphism was genotyped in 7,518 white Danish subjects using mass spectrometry analysis of PCR products. Case-control studies were undertaken for obesity, hypertension, type 2 diabetes and the metabolic syndrome, and a meta-analysis including data from the present study and previous studies of hypertension was performed. Quantitative trait studies of metabolic variables were carried out in 4,387 glucose-tolerant subjects.
resultsWe observed minor differences in 825C>T genotype distributions for type 2 diabetes (CC/CT/TT 49/41/10% (control) vs 46/46/9% (cases), respectively, p=0.007); however, after correction for multiple testing, these were not statistically significant. No association was found with hypertension, obesity or the metabolic syndrome. Curiously, the T allele was associated with nominally lower systolic and diastolic blood pressure levels-a finding in contrast with most previous studies-but not with other metabolic variables. Meta-analysis demonstrated a high degree of heterogeneity between study populations of different ethnic origin. Although there was a tendency towards an increased risk of hypertension among 825T allele carriers, this was not statistically significant. CONCLUSIONS/
interpretationThe present study suggests no major involvement of the GNB3 825C>T polymorphism in components of the metabolic syndrome.
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