ArticlePflugers Archiv : European journal of physiology2006
Integrin stimulation induces calcium signalling in rat cardiomyocytes by a NO-dependent mechanism.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical and Diagnostic Value of Highly Sensitive Cardiac Troponins in Arterial Hypertension.Vascular health and risk management · 2021Review
- Nitric Oxide and Mechano-Electrical Transduction in Cardiomyocytes.Frontiers in physiology · 2020Review
- Integrins and integrin-associated proteins in the cardiac myocyte.Circulation research · 2014Review
- ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.Biochimica et biophysica acta · 2013Review
- Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction.American journal of physiology. Cell physiology · 2013Article
- Identification of troponin I and actin, alpha cardiac muscle 1 as potential biomarkers for hearts of electrically stimulated chickens.Proteome science · 2012Article
- Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.Journal of cell science · 2009Article
- Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent.Molecular and cellular biochemistry · 2009Article
- Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.PloS one · 2008Article
- Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation.Pflugers Archiv : European journal of physiology · 2008Article
- Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.The Journal of physiology · 2007Article
- A potential role for integrin signaling in mechanoelectrical feedback.Progress in biophysics and molecular biologyReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myocardial stretch-induced increase in intracellular [Ca(2+)] ([Ca(2+)](i)) is considered to be caused by integrin stimulation. Myocardial stretch is also associated with increased nitric oxide (NO) formation. We hypothesised that NO is implicated in calcium signalling following integrin stimulation. Integrins of neonatal rat cardiomyocytes were stimulated with a pentapeptide containing the Arg-Gly-Asp (RGD) sequence. [Ca(2+)](i) was measured with Fura2, [NO](i) was measured with DAF2 and phosphorylation of focal adhesion kinase (FAK) was monitored with immunofluorescence techniques. Integrin stimulation increased both [NO](i) and [Ca(2+)](i), the latter response being inhibited by ryanodine receptor-2 (RyR2) blockers and by N(G)-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, but resistant to GdCl(3), diltiazem and wortmannin. Integrin-induced intracellular Ca(2+) release thus appears to be independent of the influx of extracellular Ca(2+) and phosphatidylinositol-3 kinase activity. In addition, integrin stimulation induced phosphorylation of FAK. Our results provide evidence for an integrin-induced Ca(2+) release from RyR2 which is mediated by NO formation, probably via FAK-induced NOS activation.
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