ArticleJournal of acquired immune deficiency syndromes (1999)2005
Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population.
Article in Journal of acquired immune deficiency syndromes (1999), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis.PloS one · 2018Pooled it
- Pooled it
- Next-generation sequencing of CCR5, CXCR4, and IFNAR1 variants in relation to HIV-1 disease progression and ART response.Scientific reports · 2025Article
- CXCL12 chemokine and CXCR4 receptor: association with susceptibility and prognostic markers in triple negative breast cancer.Molecular biology reports · 2018Article
- CXCR4 polymorphism predicts progression-free survival in metastatic colorectal cancer patients treated with first-line bevacizumab-based chemotherapy.The pharmacogenomics journal · 2017Article
- Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan andPeerJ · 2017Article
- Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder.Psychiatry investigation · 2016Article
- CCR2, CCR5, and CXCL12 variation and HIV/AIDS in Papua New Guinea.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Article
- CXCL12 genetic variants as prognostic markers in nasopharyngeal carcinoma.OncoTargets and therapy · 2015Article
- Genetic Polymorphism and Expression of CXCR4 in Breast Cancer.Analytical cellular pathology (Amsterdam) · 2015Article
- Association between SDF1-3'A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases.Molecular biology reports · 2012Article
- Genetic variants of SDF-1 and CXCR4 genes in endometrial carcinoma.Molecular biology reports · 2012Article
- The role of genetic variants of Stromal cell-Derived Factor 1 in pediatric HIV-1 infection and disease progression.PloS one · 2012Article
- Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.AIDS (London, England) · 2011Article
- Stromal cell-derived factor 1 polymorphism in patients infected with HIV and implications for AIDS progression in Tunisia.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study.International journal of immunogenetics · 2009Article
- Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics.Human genetics · 2008Review
- Host factors influencing susceptibility to HIV infection and AIDS progression.Retrovirology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
CXC chemokine ligand 12 (CXCL12), or stromal cell-derived factor 1 (SDF1), is the only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has been associated with disease progression to AIDS in some studies, but not others. Mutations in the CXCR4 gene are generally rare and have not been implicated in HIV-1/AIDS pathogenesis. This study analyzed the SDF1-3'A SNP and performed mutation screening for polymorphic markers in the CXCR4 gene to determine the presence or absence of significant associations with susceptibility to HIV-1 infection. The study consisted of 257 HIV-1-seropositive patients and 113 HIV-1-seronegative controls representing a sub-Saharan African population belonging to the Xhosa ethnic group of South Africa. The SDF1-3'A SNP was associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12. Comprehensive mutation analysis of the CXCR4 gene confirmed a high degree of genetic conservation within the coding region of this ancient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.