ArticleBiophysical journal2006
Aqueous diffusion pathways as a part of the ventricular cell ultrastructure.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange.Circulation research · 2021Article
- Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diffusional and Electrical Properties of T-Tubules Are Governed by Their Constrictions and Dilations.Biophysical journal · 2018Article
- Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle.The Journal of biological chemistry · 2016Article
- Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.Cardiovascular research · 2016Article
- Mechanisms Restricting Diffusion of Intracellular cAMP.Scientific reports · 2016Article
- Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.Nature medicine · 2014Article
- Mechanisms of cyclic AMP compartmentation revealed by computational models.The Journal of general physiology · 2014Article
- Mitochondrial colocalization with Ca2+ release sites is crucial to cardiac metabolism.Biophysical journal · 2013Article
- Action potential propagation in transverse-axial tubular system is impaired in heart failure.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Gold nanoparticle penetration and reduced metabolism in human skin by toluene.Pharmaceutical research · 2011Article
- Intracellular calcium transients evoked by pulsed infrared radiation in neonatal cardiomyocytes.The Journal of physiology · 2011Article
- MARF and Opa1 control mitochondrial and cardiac function in Drosophila.Circulation research · 2011Article
- Mitochondria in cardiomyocyte Ca2+ signaling.The international journal of biochemistry & cell biology · 2009Review
- Distribution of ryanodine receptors in rat ventricular myocytes.Journal of muscle research and cell motility · 2009Article
- Functional groups of ryanodine receptors in rat ventricular cells.The Journal of physiology · 2007Article
- cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes.The Journal of physiology · 2007Article
- Compartmentation of cAMP signaling in cardiac myocytes: a computational study.Biophysical journal · 2007Article
- Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles.Biophysical journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The physical organization of the ventricular myocyte includes barriers for the movement of objects of varying dimensions ranging from ions to solid particles. There are two kinds of diffusion in the cell: lateral (in membranes) and aqueous. Here we examine the size constraints of aqueous diffusion pathways and discuss their impact on cellular physiology. Calibrated gold nanoparticles were used to probe the accessibility of the entire transverse-axial tubular system (TATS), the sarcoplasm, and intracellular structures. The TATS tubules, although up to 300 nm in diameter, permitted only particles </=11 nm to enter. When calibrated nanoparticles were added to permeabilized ventricular cells, particles </=11 nm were found in the sarcoplasm. The distribution of nanoparticles in the cells allowed us to conclude that 1), the TATS and the sarcoplasm are accessible only for particles </=11 nm; 2), the gaps between T-tubules and junctional sarcoplasmic reticulum (jSR), jSR and mitochondria, and intermitochondrial contacts are inaccessible for particles with physical size >3 nm; 3), the mitochondrial voltage-dependent anion channel and the nuclear pore complex in ventricular cells could not be penetrated by particles >/=6 nm; and 4), there is a difference in size clearance between transversal and longitudinal sarcoplasmic diffusional pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.