ArticleNucleic acids research2005
Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Transcriptome Analysis of Different Stages in the Early Ovarian Development of the Greater Amberjack (Animals : an open access journal from MDPI · 2026Article
- In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss.Science advances · 2024Article
- Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hindsight: Review of Preclinical Disease Models for the Development of New Treatments for Uveal Melanoma.Journal of Cancer · 2021Review
- Exploring miR-9 Involvement inInternational journal of molecular sciences · 2020Article
- Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function.Oncotarget · 2018Article
- G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis.Stem cell reports · 2016Article
- Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α.Scientific reports · 2016Article
- Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina.Neurogenesis (Austin, Tex.) · 2016Article
- Cell cycle control in the early embryonic development of aquatic animal species.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- DNA and RNA derivatives to optimize distribution and delivery.Advanced drug delivery reviews · 2015Review
- Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae.PloS one · 2013Article
- Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure.Environmental health perspectives · 2012Article
- Fishing the molecular bases of Treacher Collins syndrome.PloS one · 2012Article
- Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.BMC developmental biology · 2011Article
- Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.PloS one · 2011Article
- Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells.Neural development · 2009Article
- Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
During early zebrafish (Danio rerio) development zygotic transcription does not begin until the mid-blastula transition (MBT) 3 h after fertilization. MBT demarcates transition from synchronous short cell cycles of S and M phases exclusively to full cycles encompassing G1 and G2 phases. Transcriptional profiling and RT-PCR analyses during these phases enabled us to determine that this shift corresponds to decreased transcript levels of S/M phase cell cycle control genes (e.g. ccna2, ccnb1, ccnb2 and ccne) and increased transcript levels of ccnd1, encoding cyclin D1, and orthologs of p21 (p21-like) and retinoblastoma (Rb-like 1). To investigate the regulation of this process further, the translation of ccnd1 mRNA, a G1/S checkpoint control element, was impaired by microinjection of ccnd1-specific morpholino phosphorodiamidate (MO) 20mer or hydroxyprolyl-phosphono peptide nucleic acid (HypNA-pPNA) 16mer antisense oligonucleotides. The resulting downregulation of cyclin D1 protein resulted in microophthalmia and microcephaly, but not lethality. The phenotypes were not seen with 3-mismatch MO 20mers or 1-mismatch HypNA-pPNA 16mers, and were rescued by an exogenous ccnd1 mRNA construct with five mismatches. Collectively, these results indicate that transcription of key molecular determinants of asynchronous cell cycle control in zebrafish embryos commences at MBT and that the reduction of cyclin D1 expression compromises zebrafish eye and head development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.