ArticleBMC genomics2005
Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains.
Article in BMC genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Comparative genomic analysis ofApplied and environmental microbiology · 2026Article
- Mobile gene clusters and coexpressed plant-rhizobium pathways drive partner quality variation in symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic characterization of Sinorhizobium meliloti AK21, a wild isolate from the Aral Sea Region.SpringerPlus · 2015Article
- Permanent draft genome sequences of the symbiotic nitrogen fixing Ensifer meliloti strains BO21CC and AK58.Standards in genomic sciences · 2013Article
- Large deletions in the pAtC58 megaplasmid of Agrobacterium tumefaciens can confer reduced carriage cost and increased expression of virulence genes.Genome biology and evolution · 2013Article
- Replicon-dependent bacterial genome evolution: the case of Sinorhizobium meliloti.Genome biology and evolution · 2013Article
- Population genomics of the facultatively mutualistic bacteria Sinorhizobium meliloti and S. medicae.PLoS genetics · 2012Article
- Population genomics of Sinorhizobium medicae based on low-coverage sequencing of sympatric isolates.The ISME journal · 2011Article
- Exploring the symbiotic pangenome of the nitrogen-fixing bacterium Sinorhizobium meliloti.BMC genomics · 2011Article
- A critical assessment of cross-species detection of gene duplicates using comparative genomic hybridization.BMC genomics · 2010Article
- Using comparative genomic hybridization to survey genomic sequence divergence across species: a proof-of-concept from Drosophila.BMC genomics · 2010Article
- Conserved symbiotic plasmid DNA sequences in the multireplicon pangenomic structure of Rhizobium etli.Applied and environmental microbiology · 2010Article
- Global transcriptional analysis of nitrogen fixation and ammonium repression in root-associated Pseudomonas stutzeri A1501.BMC genomics · 2010Article
- Metabolic capacity of Sinorhizobium (Ensifer) meliloti strains as determined by phenotype MicroArray analysis.Applied and environmental microbiology · 2009Article
- The alpha-proteobacteria: the Darwin finches of the bacterial world.Biology letters · 2009Article
- Characterization of hemizygous deletions in citrus using array-comparative genomic hybridization and microsynteny comparisons with the poplar genome.BMC genomics · 2008Article
- Application of physical and genetic map of Rhizobium leguminosarum bv. trifolii TA1 to comparison of three closely related rhizobial genomes.Molecular genetics and genomics : MGG · 2008Article
- Horizontal gene transfer and homologous recombination drive the evolution of the nitrogen-fixing symbionts of Medicago species.Journal of bacteriology · 2007Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSinorhizobium meliloti is a soil bacterium that forms nitrogen-fixing nodules on the roots of leguminous plants such as alfalfa (Medicago sativa). This species occupies different ecological niches, being present as a free-living soil bacterium and as a symbiont of plant root nodules. The genome of the type strain Rm 1021 contains one chromosome and two megaplasmids for a total genome size of 6 Mb. We applied comparative genomic hybridisation (CGH) on an oligonucleotide microarrays to estimate genetic variation at the genomic level in four natural strains, two isolated from Italian agricultural soil and two from desert soil in the Aral Sea region.
resultsFrom 4.6 to 5.7 percent of the genes showed a pattern of hybridisation concordant with deletion, nucleotide divergence or ORF duplication when compared to the type strain Rm 1021. A large number of these polymorphisms were confirmed by sequencing and Southern blot. A statistically significant fraction of these variable genes was found on the pSymA megaplasmid and grouped in clusters. These variable genes were found to be mainly transposases or genes with unknown function.
conclusionThe obtained results allow to conclude that the symbiosis-required megaplasmid pSymA can be considered the major hot-spot for intra-specific differentiation in S. meliloti.
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