Trial reportPsychopharmacology2006
Immediate hedonic response to smoking lapses: relationship to smoking relapse, and effects of nicotine replacement therapy.
Trial report in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nicotine replacement therapy versus control for smoking cessation.The Cochrane database of systematic reviews · 2018Pooled it
- Comparing the Effects of the EU- Versus the US-JUUL Pod in a Sample of UK Smokers: Nicotine Absorption, Satisfaction, and Other Nicotine-Related Subjective Effects.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Trial
- Impact of a Smoking Cessation Quitline in Vietnam: Evidence Base and Future Directions.International journal of environmental research and public health · 2019Trial
- Examination of the mechanism of action of two pre-quit pharmacotherapies for smoking cessation.BMC public health · 2015Trial
- Clonidine Maintenance Prolongs Opioid Abstinence and Decouples Stress From Craving in Daily Life: A Randomized Controlled Trial With Ecological Momentary Assessment.The American journal of psychiatry · 2015Trial
- An exploratory examination of the mechanisms through which pre-quit patch use aids smoking cessation.Psychopharmacology · 2014Trial
- Predictors of smoking lapse in a human laboratory paradigm.Psychopharmacology · 2014Trial
- Impact of additional counselling sessions through phone calls on smoking cessation outcomes among smokers in Penang State, Malaysia.BMC public health · 2014Trial
- Effects of varenicline on abstinence and smoking reward following a programmed lapse.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Trial
- Relapse dynamics during smoking cessation: recurrent abstinence violation effects and lapse-relapse progression.Journal of abnormal psychology · 2012Trial
- A double-blind, placebo-controlled trial of the NMDA glycine site antagonist, GW468816, for prevention of relapse to smoking in females.Journal of clinical psychopharmacology · 2011Trial
- Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression history.Psychopharmacology · 2010Trial
- Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial.Annals of internal medicine · 2010Trial
- Cigarette-by-cigarette satisfaction during ad libitum smoking.Journal of abnormal psychology · 2009Trial
- Guidelines for assessment of affect-related constructs.Frontiers in psychology · 2023Review
- ASRS Questionnaire and Tobacco Use: Not Just a Cigarette. A Screening Study in an Italian Young Adult Sample.International journal of environmental research and public health · 2021Article
- Distress Tolerance and Craving for Cigarettes Among Heavy Drinking Smokers.Journal of studies on alcohol and drugs · 2018Article
- Abstinence-induced withdrawal severity among adolescent smokers with and without ADHD: disentangling effects of nicotine and smoking reinstatement.Psychopharmacology · 2018Article
- Intermittent and daily smokers' subjective responses to smoking.Psychopharmacology · 2017Article
- Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder.Psychopharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objective and rationaleSmoking lapses represent an important juncture between smoking cessation and relapse. Nicotine replacement therapy (NRT) has been shown to decrease the risk of progression from lapse to relapse. We hypothesized that this effect might be mediated via decreases in reinforcement from smoking lapses.
methodWe assessed 169 subjects who lapsed during treatment in a double-blind placebo-controlled study of high-dose (35 mg) nicotine patch. Following their first lapse, using an electronic diary, subjects recorded the amount they smoked, and rated the pleasantness and satisfaction ("hedonic rating") and the aversiveness of smoking. Subjects were then followed and assessed for further lapses and relapses.
resultsSubjects who smoked more during the first lapse had greater risk of progression [second lapse: hazard ratio (HR)=1.16, confidence interval (CI)=1.01-1.32; relapse: HR=1.22, CI=0.97-1.54]. Subjects with higher hedonic ratings of the first lapse also had a greater risk of progression to the second lapse (HR=1.08, CI=1.02-1.14) and to relapse (HR=1.26, CI=1.11-1.41). Aversive ratings had no bearing on progression. As expected, active treatment reduced the risk of both a second lapse (HR=0.54, CI=0.39-0.78) and a relapse (HR=0.22, CI=0.11-0.45). Importantly, however, NRT had no effect on hedonic ratings, amount smoked during the first lapse, or aversive ratings.
conclusionsHedonic response to an initial lapse predicted progression to relapse, but this did not mediate the effect of NRT on progression.
Indexed as
Identifiers
16283258What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.