Evidence map›Paper›PMID 16283214›Full record

ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2005

Candida glabrata prosthetic valve endocarditis treated successfully with fluconazole plus caspofungin without surgery: a case report and literature review.

D C B Lye, A Hughes, D O'Brien, E Athan

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Guideline
  2. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009
    Guideline
  3. ISCCM Position Statement on the Management of Invasive Fungal Infections in the Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  4. Antifungal Combinations againstJournal of fungi (Basel, Switzerland) · 2022
    Review
  5. Role of Antifungal Combinations in Difficult to TreatJournal of fungi (Basel, Switzerland) · 2021
    Review
  6. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  7. Observational
  8. Article
  9. Infective endocarditis.Nature reviews. Cardiology · 2011
    Review
  10. Article
  11. Fungal endocarditis.Current infectious disease reports · 2008
    Article
  12. Candida infective endocarditis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008
    Article
  13. Surgery for infective endocarditis.Current infectious disease reports · 2007
    Article
  14. Article
  15. Article
  16. Native Valve Candida Endocarditis Complicating Pregnancy after Abdominal Surgery.Heart views : the official journal of the Gulf Heart Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

D C B LyeDepartment of Infectious Diseases, Level 7, Geelong Hospital, Ryrie Street, PO Box 281, Geelong, 3220, Victoria, Australia.
A Hughes
D O'Brien
E Athan
Geelong Hospital · AULevel (Czechia) · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reported here is the case of a 72-year-old man who was diagnosed with Candida glabrata prosthetic mitral valve endocarditis and treated successfully with fluconazole plus caspofungin after he refused and was determined unfit for surgery. Initial treatment with intravenous amphotericin B resulted in acute renal impairment. Despite 8 days of intravenous fluconazole therapy, he remained fungemic. Caspofungin was added to the treatment regimen with subsequent sterilisation of blood culture. The patient was treated for 34 days with caspofungin and 41 days with fluconazole. He continued oral fluconazole after hospital discharge and remained well at follow-up 11 months later. The role of fluconazole and caspofungin in the treatment of Candida endocarditis is discussed.

Indexed as

Candida glabrataAcute Kidney InjuryAgedAmphotericin BAntifungal AgentsCandidiasisCaspofunginDrug Therapy, CombinationEchinocandinsEndocarditisFluconazoleHeart Valve ProsthesisHumansLipopeptidesMaleMitral ValveAmphotericin BAntifungal AgentsCaspofunginEchinocandinsFluconazoleLipopeptidesPeptides, Cyclic

Identifiers

PMID16283214
OpenAlexW2064226901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.