ArticlePflugers Archiv : European journal of physiology2006
Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Role of transient receptor potential channels on pathogenesis and treatment of psoriasis.Inflammopharmacology · 2026Review
- Wound Repair and CaCells · 2024Review
- TRPC1 channel clustering during store-operated CaFrontiers in physiology · 2023Article
- Store-operated calcium channels in skin.Frontiers in physiology · 2022Review
- Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases.Frontiers in pharmacology · 2021Review
- Skin Barrier and Calcium.Annals of dermatology · 2018Review
- Neurological and Motor Disorders: Neuronal Store-Operated CaAdvances in experimental medicine and biology · 2017Review
- TRP channels in skin: from physiological implications to clinical significances.Biophysics (Nagoya-shi, Japan) · 2015Review
- Defective channels lead to an impaired skin barrier.Journal of cell science · 2014Review
- Reversal of murine epidermal atrophy by topical modulation of calcium signaling.The Journal of investigative dermatology · 2014Article
- TRP channels in the skin.British journal of pharmacology · 2014Review
- Article
- ORAI1 calcium channel orchestrates skin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?British journal of pharmacology · 2013Review
- Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation.Journal of cell science · 2013Article
- Contribution and regulation of TRPC channels in store-operated Ca2+ entry.Current topics in membranes · 2013Review
- Calcium regulation of keratinocyte differentiation.Expert review of endocrinology & metabolism · 2012Article
- Critical role of TRPC1-mediated Ca²⁺ entry in decidualization of human endometrial stromal cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions.PLoS biology · 2011Article
- Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
External calcium ion concentration is a major regulator of epidermal keratinocyte differentiation in vitro and probably also in vivo. Regulation of calcium-induced differentiation changes is proposed to occur via an external calcium-sensing, signaling pathway that utilizes increases in intracellular calcium ion concentration to activate differentiation-related gene expression. Calcium ion release from intracellular stores and calcium ion influx via store-operated calcium-permeable channels are key elements in this proposed signaling pathway; however, the channels involved have not yet been identified. The present report shows that human gingival keratinocytes (HGKs) also undergo calcium-induced differentiation in vitro as indicated by involucrin expression and morphological changes. Moreover, TRPC1, which functions as a store-operated calcium channel in a number of cell types, including epidermal keratinocytes, is expressed in both proliferating and differentiating HGKs. Transfection of HGKs with TRPC1 siRNA disrupted expression of TRPC1 mRNA and protein compared with transfection with scrambled TRPC1 siRNA. Cells with disrupted TRPC1 expression showed decreased calcium-induced differentiation as measured by involucrin expression or morphological changes, as well as decreased thapsigargin-induced calcium ion influx, and a decreased rate of store calcium release. These results indicate that TRPC1 is involved in calcium-induced differentiation of HGKs likely by supporting a store-operated calcium ion influx.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.