ReviewCurrent opinion in pediatrics2005
Progress toward discerning the genetics of cleft lip.
Review in Current opinion in pediatrics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Genetic and Molecular Basis of Cleft Lip and Palate: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2026Review
- Craniofacial Development: Neural Crest in Molecular Embryology.Head and neck pathology · 2021Review
- Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes.European journal of human genetics : EJHG · 2018Article
- Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate.Clinical oral investigations · 2018Article
- Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface.Journal of anatomy · 2018Article
- Copy Number Changes Identified Using Whole Exome Sequencing in Nonsyndromic Cleft Lip and Palate in a Honduran Population.Birth defects research · 2017Article
- [Cleft lip and palate].Der Pathologe · 2017Review
- A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate.Experimental and therapeutic medicine · 2017Article
- Dissection of the complex genetic basis of craniofacial anomalies using haploid genetics and interspecies hybrids in Nasonia wasps.Developmental biology · 2016Article
- Racial Variations in Velopharyngeal and Craniometric Morphology in Children: An Imaging Study.Journal of speech, language, and hearing research : JSLHR · 2016Article
- Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.Molecular genetics & genomic medicine · 2015Article
- Long-term effects of oral clefts on health care utilization: a sibling comparison.The European journal of health economics : HEPAC : health economics in prevention and care · 2015Article
- GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk.International journal of clinical and experimental medicine · 2015Article
- Developmental profiles of the murine palatal methylome.Birth defects research. Part A, Clinical and molecular teratology · 2013Article
- Epigenetic regulation of Sox4 during palate development.Epigenomics · 2013Article
- The effects of oral clefts on hospital use throughout the lifespan.BMC health services research · 2012Article
- Implications of TGFβ on Transcriptome and Cellular Biofunctions of Palatal Mesenchyme.Frontiers in physiology · 2012Article
- Genetics of nonsyndromic orofacial clefts.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2012Review
- A comprehensive review of the genetic basis of cleft lip and palate.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Roles of BMP signaling pathway in lip and palate development.Frontiers of oral biology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewOrofacial clefts are common birth defects with a known genetic component to their etiology. Most orofacial clefts are nonsyndromic, isolated defects, which can be separated into two different phenotypes: (1) cleft lip with or without cleft palate and (2) cleft palate only. Both are genetically complex traits, which has limited the ability to identify disease loci or genes. The purpose of this review is to summarize recent progress of human genetic studies in identifying causal genes for isolated or nonsyndromic cleft lip with or without cleft palate. RECENT
findingsThe results of multiple genome scans and a subsequent meta-analysis have significantly advanced our knowledge by revealing novel loci. Furthermore, candidate gene approaches have identified important roles for IRF6 and MSX1. To date, causal mutations with a known functional effect have not yet been described. SUMMARY: With the implementation of genome-wide association studies and inexpensive sequencing, future studies will identify disease genes and characterize both gene-environment and gene-gene interactions to provide knowledge for risk counseling and the development of preventive therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.