ArticleThe EMBO journal2005
The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Pancreatic cancer induces B cell lineage plasticity via Pax5 inhibition to sustain immunosuppression.Cell death discovery · 2026Article
- Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation.Nature communications · 2021Article
- It Takes Three Receptors to Raise a B Cell.Trends in immunology · 2020Review
- Cell circuits and niches controlling B cell development.Immunological reviews · 2019Review
- The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.Nature immunology · 2017Article
- Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.Nature immunology · 2017Article
- The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development.Cell reports · 2016Article
- DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.The Journal of experimental medicine · 2015Article
- Checkpoints that control B cell development.The Journal of clinical investigation · 2015Review
- Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.Nature reviews. Immunology · 2014Review
- Combined immunofluorescence and DNA FISH on 3D-preserved interphase nuclei to study changes in 3D nuclear organization.Journal of visualized experiments : JoVE · 2013Article
- A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5.Molecular and cellular biology · 2012Article
- Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling.Nature reviews. Immunology · 2009Review
- The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
- Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.PloS one · 2008Article
- Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion.The EMBO journal · 2007Article
- Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The pre-B-cell receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion. We have investigated whether the pre-BCR also signals downregulation of the SLC genes (VpreB and lambda5), thereby limiting this expansion. We demonstrate that, as BM cells progress from the pre-BI to large pre-BII-cell stage, there is a shift from bi- to mono-allelic lambda5 transcription, while the second allele is silenced in small pre-BII cells. A VpreB1-promoter-driven transgene shows the same pattern, therefore suggesting that VpreB1 is similarly regulated and thereby defines the promoter as a target for transcriptional silencing. Analyses of pre-BCR-deficient mice show a temporal delay in lambda5 downregulation, thereby demonstrating that the pre-BCR is essential for monoallelic silencing at the large pre-BII-cell stage. Our data also suggest that SLP-65 is one of the signaling components important for this process. Furthermore, the VpreB1/lambda5 alleles undergo dynamic changes with respect to nuclear positioning and heterochromatin association, thereby providing a possible mechanism for their transcriptional silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.