ArticleProceedings of the National Academy of Sciences of the United States of America2005
Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.PloS one · 2012Article
- Gene expression profiles in a rabbit model of systemic lupus erythematosus autoantibody production.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- Quantitation of cytokine mRNA by real-time RT-PCR during a vaccination trial in a rabbit model of fascioliasis.Veterinary parasitology · 2010Article
- Temporal regulation of Ig gene diversification revealed by single-cell imaging.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Active nuclear import and cytoplasmic retention of activation-induced deaminase.Nature structural & molecular biology · 2009Article
- Expression and localization of rabbit B-cell activating factor (BAFF) and its specific receptor BR3 in cells and tissues of the rabbit immune system.Developmental and comparative immunology · 2009Article
- Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.DNA repair · 2008Article
- Quantitation of rabbit cytokine mRNA by real-time RT-PCR.Cytokine · 2007Article
- Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination.Critical reviews in immunology · 2007Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Studies in mouse, human, and chicken suggest that activation-induced deaminase (AID) is involved in three known processes leading to antibody diversification: somatic hypermutation, gene conversion, and class-switch recombination. Developing rabbit appendix provides a particularly good site for studying all three of these B cell maturation events. We report here successful cloning of rabbit AID and isolation of AID protein from rabbit appendix-cell nuclear and cytoplasmic extracts. We succeeded in identifying and locating AID protein in cells by immunohistochemical and immunofluorescent staining techniques and examined colocalization of AID and other molecules important for Ab diversification. This report extends our knowledge about AID to a mammalian species that uses gene conversion to diversify rearranged Ig genes. Although much work remains to understand fully the mechanism of action of AID and its association with other cellular components, the rabbit system now offers a particularly useful model for future studies of these dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.