ArticleThe FEBS journal2005
Chromosomal protein HMGN1 modulates the expression of N-cadherin.
Article in The FEBS journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Do Alarmins Have a Role in Multiple Myeloma?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- Function of chromatin modifier Hmgn1 during neural crest and craniofacial development.Genesis (New York, N.Y. : 2000) · 2021Article
- Biological Functions of HMGN Chromosomal Proteins.International journal of molecular sciences · 2020Review
- CRISPR-Induced TMPRSS2-ERG Gene Fusions in Mouse Prostate Organoids.JSM biotechnology & biomedical engineering · 2017Article
- Alarmins and Antitumor Immunity.Clinical therapeutics · 2016Review
- Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression.Cancer research · 2016Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- The chromosomal protein HMGN2 mediates the LPS-induced expression of β-defensins in mice.Inflammation · 2012Article
- The nucleosome binding protein HMGN3 is expressed in pancreatic alpha-cells and affects plasma glucagon levels in mice.Journal of cellular biochemistry · 2010Article
- HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.Molecular cell · 2009Article
- Chromosomal protein HMGN1 enhances the heat shock-induced remodeling of Hsp70 chromatin.The Journal of biological chemistry · 2008Article
- HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.Molecular and cellular biology · 2007Article
- Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement.Neoplasia (New York, N.Y.) · 2006Article
- A role for chromosomal protein HMGN1 in corneal maturation.Differentiation; research in biological diversity · 2006Article
- HMGNs, DNA repair and cancer.Biochimica et biophysica actaReview
- Developmental function of HMGN proteins.Biochimica et biophysica actaReview
- Transcriptional regulation by HMGN proteins.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
HMGN1 is a nuclear protein that binds to nucleosomes and alters the accessibility of regulatory factors to their chromatin targets. To elucidate its biological function and identify specific HMGN1 target genes, we generated Hmgn1-/- mice. DNA microarray analysis of Hmgn1+/+ and Hmgn1-/- embryonic fibroblasts identified N-cadherin as a potential HMGN1 gene target. RT-PCR and western blot analysis confirmed a linkage between HMGN1 expression and N-cadherin levels. In both transformed and primary mouse embryonic fibroblasts (MEFs), HMGN1 acted as negative regulator of N-cadherin expression. Likewise, the N-cadherin levels in early embryos of Hmgn1-/- mice were higher than those of their Hmgn1+/+ littermates. Loss of HMGN1 increased the adhesiveness, motility and aggregation potential of Hmgn1-/- MEFs, a phenotype consistent with increased levels of N-cadherin protein. Re-expression of wild-type HMGN1, but not of the mutant HMGN1 protein that does not bind to chromatin, in Hmgn1-/- MEFs, decreased the levels of N-cadherin and restored the Hmgn1+/+ phenotype. These studies demonstrate a role for HMGN1 in the regulation of specific gene expression. We suggest that in MEFs, and during early mouse development, the interaction of HMGN1 with chromatin down-regulates the expression of N-cadherin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.