ArticleBiopolymers2006
Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids.
Article in Biopolymers, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Article
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- Fast viral dynamics revealed by microsecond time-resolved cryo-EM.Nature communications · 2023Article
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- Contact-Based Analysis of Aggregation of Intrinsically Disordered Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Subset of Fluorophores Is Responsible for Radiation Brightening in Viromimetic Particles.The journal of physical chemistry. B · 2021Article
- Antiviral therapy in shrimp through plant virus VLP containing VP28 dsRNA against WSSV.Beilstein journal of organic chemistry · 2021Article
- Genome organization and interaction with capsid protein in a multipartite RNA virus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses.Biophysical journal · 2018Article
- Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In Vivo.Human gene therapy · 2018Article
- Self-assembly of model proteins into virus capsids.Journal of physics. Condensed matter : an Institute of Physics journal · 2017Article
- AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Swelling and softening of the cowpea chlorotic mottle virus in response to pH shifts.Biophysical journal · 2015Article
- Synthetic immunosurveillance systems: nanodevices to monitor physiological events.Biosensors & bioelectronics · 2014Review
- Collective variable approaches for single molecule flexible fitting and enhanced sampling.Chemical reviews · 2014Review
- iAPBS: a programming interface to Adaptive Poisson-Boltzmann Solver (APBS).Computational science & discovery · 2012Article
- Virus capsid dissolution studied by microsecond molecular dynamics simulations.PLoS computational biology · 2012Article
- Viral capsid equilibrium dynamics reveals nonuniform elastic properties.Biophysical journal · 2011Article
- All-atom multiscale simulation of cowpea chlorotic mottle virus capsid swelling.The journal of physical chemistry. B · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Electrostatic properties of cowpea chlorotic mottle virus (CCMV) and cucumber mosaic virus (CMV) were investigated using numerical solutions to the Poisson-Boltzmann equation. Experimentally, it has been shown that CCMV particles swell in the absence of divalent cations when the pH is raised from 5 to 7. CMV, although structurally homologous, does not undergo this transition. An analysis of the calculated electrostatic potential confirms that a strong electrostatic repulsion at the calcium-binding sites in the CCMV capsid is most likely the driving force for the capsid swelling process during the release of calcium. The binding interaction between the encapsulated genome material (RNA) inside of the capsid and the inner capsid shell is weakened during the swelling transition. This probably aids in the RNA release process, but it is unlikely that the RNA is released through capsid openings due to unfavorable electrostatic interaction between the RNA and capsid inner shell residues at these openings. Calculations of the calcium binding energies show that Ca(2+) can bind both to the native and swollen forms of the CCMV virion. Favorable binding to the swollen form suggests that Ca(2+) ions can induce the capsid contraction and stabilize the native form.
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Registered trials
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