Trial reportEuropean journal of clinical nutrition2006
Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women.
Trial report in European journal of clinical nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- The Effects of Diet and Exercise on Endogenous Estrogens and Subsequent Breast Cancer Risk in Postmenopausal Women.Frontiers in endocrinology · 2021Pooled it
- Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation.Nutrients · 2019Pooled it
- Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin FRedox biology · 2018Pooled it
- Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis.Current atherosclerosis reports · 2011Pooled it
- Changes in fatty acid levels after consumption of a novel docosahexaenoic supplement from algae: a crossover randomized controlled trial in omnivorous, lacto-ovo vegetarians and vegans.European journal of nutrition · 2023Trial
- Trial
- Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults.The Journal of nutrition · 2011Trial
- Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents.Frontiers in nutrition · 2023Article
- Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified DHA Supplementation.Antioxidants (Basel, Switzerland) · 2020Article
- Article
- The Effects of Soy Milk Enriched with Lactobacillus casei and Omega-3 on the Tibia and L5 Vertebra in Diabetic Rats: a Stereological Study.Probiotics and antimicrobial proteins · 2019Article
- Long-chainJournal of nutritional science · 2017Review
- Oxidative stress in relation to diet and physical activity among premenopausal women.The British journal of nutrition · 2016Observational
- Which has the stronger impact on coronary artery disease, eicosapentaenoic acid or docosahexaenoic acid?Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals.Lipids in health and disease · 2015Review
- Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative.The American journal of clinical nutrition · 2015Article
- DHA concentration of red blood cells is inversely associated with markers of lipid peroxidation in men taking DHA supplement.Journal of clinical biochemistry and nutrition · 2014Article
- A new insight to bone turnover: role of ω-3 polyunsaturated fatty acids.TheScientificWorldJournal · 2013Review
- Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women.Nutrition & metabolism · 2013Article
- Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans.The Journal of nutrition · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVegetarians are generally deficient in long-chain n-3 fatty acids. Long-chain n-3 fatty acids have a beneficial effect on plasma lipid levels, and some studies showed that they had breast cancer suppression effect. One of the biomarkers of breast cancer risk is the ratio of urinary 2-hydroxyestrone (2-OHE(1)) to 16alpha-hydroxyestrone (16alpha-OHE(1)).
objectiveTo investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) supplementation on blood lipids, estrogen metabolism and oxidative stress in vegetarians.
designSingle-blind, randomized, placebo-controlled trial.
interventionsTwenty-seven postmenopausal vegetarian women were recruited. After a 2-week run-in period with 6 g placebo corn oil, the subjects were subsequently randomized to receive either 6 g corn oil (n=13) or 6 g DHA-rich algae oil (2.14 g of DHA/day) (n=14) for 6 weeks. Two subjects in corn oil group withdrew before completion.
main outcome measuresPlasma lipids, urinary 2-OHE(1) and 16alpha-OHE(1), urinary F(2)-isoprostanes and plasma alpha-tocopherol.
resultsPlasma LDL-DHA and EPA level increased significantly by DHA supplementation. DHA decreased plasma cholesterol (C) levels (P=0.04), but did not influence the levels of plasma TG, LDL-C and HDL-C, alpha-tocopherol, urinary F(2)-isoprostanes, 2-OHE(1), 16alpha-OHE(1) and ratio of 2-OHE(1) to 16alpha-OHE(1) as compared to corn oil.
conclusionDHA supplementation at a dose of 2.14 g/day for 42 days decreases plasma cholesterol but neither does it show beneficial effects on estrogen metabolism, nor does it induce deleterious effects on the observed in vivo antioxidant or oxidative stress marker in postmenopausal vegetarian women. SPONSORSHIP: A grant (# DOH89-TD-1062) from Department of Health, Executive Yuan, Taiwan.
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Registered trials
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