ArticleEukaryotic cell2005
A Rho-type GTPase, rho-4, is required for septation in Neurospora crassa.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- A Rho-Type GTPase Protein Pocdc42 Regulates the Development and Cellulase Expression of Penicillium oxalicum.Current microbiology · 2025Article
- The Small Ras Superfamily GTPase Rho4 of the Maize Anthracnose FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Review
- Actin Is Required for Cellular Development and Virulence ofmSystems · 2020Article
- CRISPR/Cas9-mediated endogenous gene tagging in Fusarium oxysporum.Fungal genetics and biology : FG & B · 2019Article
- A Small GTPase RHO2 Plays an Important Role in Pre-infection Development in the Rice Blast PathogenThe plant pathology journal · 2018Article
- FgBud3, a Rho4-Interacting Guanine Nucleotide Exchange Factor, Is Involved in Polarity Growth, Cell Division and Pathogenicity ofFrontiers in microbiology · 2018Article
- Cell Biology of Hyphal Growth.Microbiology spectrum · 2017Review
- Protein phosphatase 2A (PP2A) regulatory subunits ParA and PabA orchestrate septation and conidiation and are essential for PP2A activity in Aspergillus nidulans.Eukaryotic cell · 2014Article
- Proper actin ring formation and septum constriction requires coordinated regulation of SIN and MOR pathways through the germinal centre kinase MST-1.PLoS genetics · 2014Article
- STRIPAK complexes: structure, biological function, and involvement in human diseases.The international journal of biochemistry & cell biology · 2014Review
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- Article
- Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2.Eukaryotic cell · 2013Article
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- Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction.The Journal of cell biology · 2011Article
- Actin organization and dynamics in filamentous fungi.Nature reviews. Microbiology · 2011Review
- Functional characterization and cellular dynamics of the CDC-42 - RAC - CDC-24 module in Neurospora crassa.PloS one · 2011Article
- A mutant defective in sexual development produces aseptate ascogonia.Eukaryotic cell · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins in the Rho family are small monomeric GTPases primarily involved in polarization, control of cell division, and reorganization of cytoskeletal elements. Phylogenetic analysis of predicted fungal Rho proteins suggests that a new Rho-type GTPase family, whose founding member is Rho4 from the archiascomycete Schizosaccharomyces pombe, is involved in septation. S. pombe rho4Delta mutants have multiple, abnormal septa. In contrast to S. pombe rho4Delta mutants, we show that strains containing rho-4 loss-of-function mutations in the filamentous fungus Neurospora crassa lead to a loss of septation. Epitope-tagged RHO-4 localized to septa and to the plasma membrane. In other fungi, the steps required for septation include formin, septin, and actin localization followed by cell wall synthesis and the completion of septation. rho-4 mutants were unable to form actin rings, showing that RHO-4 is required for actin ring formation. Characterization of strains containing activated alleles of rho-4 showed that RHO-4-GTP is likely to initiate new septum formation in N. crassa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.