ArticleEukaryotic cell2005
Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Transport of sphingolipids by yeast Npc2 supports phase separation of the vacuole membrane.bioRxiv : the preprint server for biology · 2025Article
- Dynamic mode decomposition for analysis and prediction of metabolic oscillations from time-lapse imaging of cellular autofluorescence.Scientific reports · 2025Article
- Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein.Life science alliance · 2025Article
- Automated quantification of vacuole fusion and lipophagy inAutophagy · 2024Article
- Iron Limitation Restores Autophagy and Increases Lifespan in the Yeast Model of Niemann-Pick Type C1.International journal of molecular sciences · 2023Article
- Article
- A lysosomal biogenesis map reveals the cargo spectrum of yeast vacuolar protein targeting pathways.The Journal of cell biology · 2022Article
- Article
- Understanding and Treating Niemann-Pick Type C Disease: Models Matter.International journal of molecular sciences · 2020Review
- Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms inIndian journal of microbiology · 2017Review
- Article
- Host-to-pathogen gene transfer facilitated infection of insects by a pathogenic fungus.PLoS pathogens · 2014Article
- Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Molecular microbiology · 2014Article
- Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM.Traffic (Copenhagen, Denmark) · 2011Article
- Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1.Traffic (Copenhagen, Denmark) · 2011Article
- Mining for genotype-phenotype relations in Saccharomyces using partial least squares.BMC bioinformatics · 2011Article
- An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.The Journal of biological chemistry · 2011Article
- Sterols and sphingolipids: dynamic duo or partners in crime?Progress in lipid research · 2010Review
- Niemann-Pick type C pathogenesis and treatment: from statins to sugars.Clinical lipidology · 2010Article
- A Drosophila protein family implicated in pheromone perception is related to Tay-Sachs GM2-activator protein.The Journal of biological chemistry · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Niemann-Pick Disease Type C (NP-C) is a fatal neurodegenerative disease, which is biochemically distinguished by the lysosomal accumulation of exogenously derived cholesterol. Mutation of either the hNPC1 or hNPC2 gene is causative for NP-C. We report the identification of the yeast homologue of human NPC2, Saccharomyces cerevisiae Npc2p. We demonstrate that scNpc2p is evolutionarily related to the mammalian NPC2 family of proteins. We also show, through colocalization, subcellular fractionation, and secretion analyses, that yeast Npc2p is treated similarly to human NPC2 when expressed in mammalian cells. Importantly, we show that yeast Npc2p can efficiently revert the unesterified cholesterol and GM1 accumulation seen in hNPC2-/- patient fibroblasts demonstrating that it is a functional homologue of human NPC2. The present study reveals that the fundamental process of NPC2-mediated lipid transport has been maintained throughout evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.