ArticleMalaria journal2005
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya.
Article in Malaria journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Blood group antigens and malaria susceptibility.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Population-specific positive selection on low CR1 expression in malaria-endemic regions.PloS one · 2023Article
- Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island.Molecular biology and evolution · 2022Article
- Rosetting revisited: a critical look at the evidence for host erythrocyte receptors inParasitology · 2020Review
- Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm.Frontiers in immunology · 2019Review
- Two complement receptor one alleles have opposing associations with cerebral malaria and interact with αeLife · 2018Article
- No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.Scientific reports · 2017Article
- Red blood cell complement receptor one level varies with Knops blood group, α(+)thalassaemia and age among Kenyan children.Genes and immunity · 2016Article
- Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection.Frontiers in immunology · 2016Review
- Severity of malaria in relation to a complement receptor 1 polymorphism: a case-control study.Pathogens and global health · 2015Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
- Extensive genomic variability of knops blood group polymorphisms is associated with sickle cell disease in Africa.Evolutionary bioinformatics online · 2015Article
- Human gene copy number variation and infectious disease.Human genetics · 2014Review
- Article
- Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern Ghana.Malaria journal · 2013Article
- Article
- Possible influence of resistance to malaria in clinical presentation of rheumatoid arthritis: biological significance of natural selection.Arthritis · 2012Article
- Sickle cell protection from malaria.Hematology reports · 2011Article
- Evidence for malaria selection of a CR1 haplotype in Sardinia.Genes and immunity · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIt has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated.
methodsTo test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out.
resultsNo significant association was found between the African alleles and severe malaria-associated anaemia. However, children with Sl2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95% CI 0.04 to 0.72, P = 0.02) than children with Sl1/1. In particular, individuals with Sl2/2 McC(a/b) genotype were less likely to have cerebral malaria (OR = 0.18, 95% CI 0.04 to 0.77, P = 0.02) than individuals with Sl1/1 McC(a/a).
conclusionThese results support the hypothesis that the Sl2 allele and, possibly, the McCb allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations.
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