ArticlePLoS biology2005
Impaired DNA replication within progenitor cell pools promotes leukemogenesis.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
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- Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors.The Journal of experimental medicine · 2021Article
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- Too much to handle - how gaining chromosomes destabilizes the genome.Cell cycle (Georgetown, Tex.) · 2016Review
- Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.The Journal of clinical investigation · 2015Article
- Second generation tyrosine kinase inhibitors prevent disease progression in high-risk (high CIP2A) chronic myeloid leukaemia patients.Leukemia · 2015Article
- Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.Cell stem cell · 2015Review
- Replication stress and cancer.Nature reviews. Cancer · 2015Review
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- Impact of genomic damage and ageing on stem cell function.Nature cell biology · 2014Review
- Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Oncogene · 2013Review
- DNA damage checkpoints in stem cells, ageing and cancer.Nature reviews. Molecular cell biology · 2012Review
- Evolved tumor suppression: why are we so good at not getting cancer?Cancer research · 2011Article
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- Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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- Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.Cell cycle (Georgetown, Tex.) · 2010Article
- Irradiation selects for p53-deficient hematopoietic progenitors.PLoS biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Impaired cell cycle progression can be paradoxically associated with increased rates of malignancies. Using retroviral transduction of bone marrow progenitors followed by transplantation into mice, we demonstrate that inhibition of hematopoietic progenitor cell proliferation impairs competition, promoting the expansion of progenitors that acquire oncogenic mutations which restore cell cycle progression. Conditions that impair DNA replication dramatically enhance the proliferative advantage provided by the expression of Bcr-Abl or mutant p53, which provide no apparent competitive advantage under conditions of healthy replication. Furthermore, for the Bcr-Abl oncogene the competitive advantage in contexts of impaired DNA replication dramatically increases leukemogenesis. Impaired replication within hematopoietic progenitor cell pools can select for oncogenic events and thereby promote leukemia, demonstrating the importance of replicative competence in the prevention of tumorigenesis. The demonstration that replication-impaired, poorly competitive progenitor cell pools can promote tumorigenesis provides a new rationale for links between tumorigenesis and common human conditions of impaired DNA replication such as dietary folate deficiency, chemotherapeutics targeting dNTP synthesis, and polymorphisms in genes important for DNA metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.