ArticleJournal of the American Chemical Society2005
Detection of homocysteine and cysteine.
Article in Journal of the American Chemical Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 587 citations in OpenAlex.
- Highly Sensitive "On-off" Fluorescent Probe TPA-DNBS Based on Triphenylamine Derivative for Selective Detection of Cysteine.Journal of fluorescence · 2026Article
- A selective fluorescent probe for an organophosphorous nerve agent mimicRSC advances · 2026Article
- A review of metal ion complexation/decomplexation reaction-based fluorescent sensors for detecting biological thiols.RSC advances · 2025Review
- Quantum-Dot-Based Molecularly Imprinted Hydrogel for Rapid Detection of Homocysteine.Gels (Basel, Switzerland) · 2025Article
- Review
- Smart Probes for Ultrasensitive and Highly Selective Sensing of Homocysteine over Cysteine Based on Multi-Cooperative Effects by Using Gold Nanoparticles.Molecules (Basel, Switzerland) · 2025Article
- Colorimetric sensing for translational applications: from colorants to mechanisms.Chemical Society reviews · 2024Review
- Analytical developments in the synergism of copper particles and cysteine: a review.Nanoscale advances · 2024Review
- Challenges and Opportunities of Using Fluorescent Metal Nanocluster-Based Colorimetric Assays in Medicine.ACS omega · 2024Review
- Applications of Pyrrole and Pyridine-based Heterocycles in Cancer Diagnosis and Treatment.Current pharmaceutical design · 2024Review
- Atomic electronegativity-dependent intramolecular hydrogen bond and fluorescence characteristics of novel scaffold-based fluorophore: a TD-DFT study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Manipulating the monomer-dimer transformation of a heptamethine cyanine ligand: near infrared chromogenic recognition of biothiols.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- More Effective Mobilization of HgToxics · 2023Article
- Selective Homocysteine Assay with Cucurbit[7]uril by pH Regulation.Journal of microbiology and biotechnology · 2022Article
- Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.Chemical reviews · 2022Review
- A Facile Probe for Fluorescence Turn-on and Simultaneous Naked-Eyes Discrimination of HJournal of fluorescence · 2022Article
- Identifying a role for the interaction of homocysteine and copper in promoting cardiovascular-related damage.Amino acids · 2021Article
- A 3,5-dinitropyridin-2yl substituted naphthalimide-based fluorescent probe for the selective detection of biothiols and its application in cell-imaging.RSC advances · 2021Article
- A Turn-on Fluorescent Probe for the Discrimination of Cys/Hcy and GSH With Dual Emission Signals.Journal of fluorescence · 2021Article
- Controlled "off-on" fluorescent probe for the specific detection of hyperhomocysteinemia.RSC advances · 2021Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
At elevated levels, homocysteine (Hcy, 1) is a risk factor for cardiovascular diseases, Alzheimer's disease, neural tube defects, and osteoporosis. Both 1 and cysteine (Cys, 3) are linked to neurotoxicity. The biochemical mechanisms by which 1 and 3 are involved in disease states are relatively unclear. Herein, we describe simple methods for detecting either Hcy or Cys in the visible spectral region with the highest selectivity reported to date without using biochemical techniques or preparative separations. Simple methods and readily available reagents allow for the detection of Cys and Hcy in the range of their physiologically relevant levels. New HPLC postcolumn detection methods for biological thiols are reported. The potential biomedical relevance of the chemical mechanisms involved in the detection of 1 is described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.