ArticleEuropean journal of immunology2005
Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling.
Article in European journal of immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Persistent CD4Cellular immunology · 2026Article
- CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.Nature communications · 2022Article
- A population of CD4Clinical & translational immunology · 2020Article
- Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques.Journal of immunology research · 2020Article
- Coreceptors and TCR Signaling - the Strong and the Weak of It.Frontiers in cell and developmental biology · 2020Review
- Dual Role of CD4 in Peripheral T Lymphocytes.Frontiers in immunology · 2019Review
- Exposure of Human CD8Frontiers in immunology · 2018Article
- Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun.Scientific reports · 2017Article
- Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.BMC biology · 2014Article
- Boosting regulatory T cell function by CD4 stimulation enters the clinic.Frontiers in immunology · 2012Article
- Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk.Clinical immunology (Orlando, Fla.) · 2009Article
- Article
- Signals for the execution of Th2 effector function.Cytokine · 2009Review
- Th1 and Th2 cells form morphologically distinct immunological synapses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Polarized Th1 and Th2 cells expressing the same TCR produce distinct biochemical responses to ligand engagement. Compared to Th1 cells, Th2 cells show altered substrate tyrosine phosphorylation and a diminished or transient Ca2+ response. Here we demonstrate that agonist stimulation of Th1 cells leads to the predominant appearance of fully phosphorylated (p23) TCR zeta, substantial phosphorylation of zeta-associated protein 70 (ZAP-70), and strong elevation of intracellular Ca2+, whereas agonist stimulation of Th2 cells expressing an identical TCR results in an elevated p21:p23 TCR zeta ratio, little or no detectable ZAP-70 phosphorylation, and a more limited elevation in intracellular Ca2+. Th2 cells consistently had twofold lower surface CD4 expression as compared to Th1 cells with the same TCR. When CD4 levels in Th2 cells were raised to Th1 levels using retroviral gene transfer, the transduced cells showed greater generation of p23 phospho-zeta, measurable phosphorylation of ZAP-70, and increased Ca2+ responses. These findings suggest that the apparent qualitative differences in TCR signaling characterizing Th1 versus Th2 cells are largely the result of modest quantitative variation in CD4 expression, with decreased CD4 expression playing a significant role in attenuating the proximal signaling responsiveness of Th2 cells to TCR ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.