ArticleThe Journal of clinical investigation2005
CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
223 citing papers in PubMed, 4 syntheses or guidelines pooled it, 627 citations in OpenAlex.
- The role of CD36 in immune function: bridging innate and adaptive responses.Frontiers in immunology · 2026Pooled it
- Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review.Frontiers in genetics · 2019Pooled it
- Pooled it
- Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.PloS one · 2012Pooled it
- The role of lipolysis in human orosensory fat perception.Journal of lipid research · 2014Trial
- The examination of fatty acid taste with edible strips.Physiology & behavior · 2012Trial
- Dynamics of fat absorption and effect of sham feeding on postprandial lipema.Gastroenterology · 2010Trial
- Establishment of a Three-Dimensional In Vitro Model of Taste Bud Cells for Fat Taste Investigation.International journal of molecular sciences · 2026Article
- Characterization and postprandial regulation of the nutrient-sensing machinery in the oral floor mucosa of 10-week-old mule ducks.Poultry science · 2026Article
- A Hypothesis-Based Framework for Chicken Meat Palatability: Proposing Indirect Roles of Arachidonic Acid and Lipid Oxidation.Animals : an open access journal from MDPI · 2026Review
- Associations of taste receptor gene variants with Body Mass Index (BMI) and longevity.Scientific reports · 2026Article
- CD36 and Its Role in Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Unveiling the Small Molecules Binding Site of CD36 Cell Surface Receptor Through Docking and Molecular Dynamics Simulations.Current medicinal chemistry · 2026Article
- Improving oral fat sensitivity measurement and evaluating key fat types using a modified signal detection approach and additive-free milk-based emulsions.Food science and biotechnology · 2025Article
- Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery.Obesity (Silver Spring, Md.) · 2025Article
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Effects of a Plant-Based Diet During the First Month of Feeding on Alevin Rainbow Trout (Aquaculture nutrition · 2025Article
- CREB coactivator CRTC1 in melanocortin-4 receptor-expressing cells regulate dietary fat intake.FASEB bioAdvances · 2024Article
- Article
- Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice.The journal of physiological sciences : JPS · 2024Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rats and mice exhibit a spontaneous attraction for lipids. Such a behavior raises the possibility that an orosensory system is responsible for the detection of dietary lipids. The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (LCFAs) and is found in lingual papillae in the rat. To explore this hypothesis further, experiments were conducted in rats and in wild-type and CD36-null mice. In mice, RT-PCR experiments with primers specific for candidate lipid-binding proteins revealed that only CD36 expression was restricted to lingual papillae although absent from the palatal papillae. Immunostaining studies showed a distribution of CD36 along the apical side of circumvallate taste bud cells. CD36 gene inactivation fully abolished the preference for LCFA-enriched solutions and solid diet observed in wild-type mice. Furthermore, in rats and wild-type mice with an esophageal ligation, deposition of unsaturated LCFAs onto the tongue led to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.