ArticleProstate cancer and prostatic diseases2006
Brn-3a neuronal transcription factor functional expression in human prostate cancer.
Article in Prostate cancer and prostatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- MethReg: estimating the regulatory potential of DNA methylation in gene transcription.Nucleic acids research · 2022Article
- HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma.International journal of molecular sciences · 2022Article
- Progesterone Receptor Expression in the Benign Prostatic Hyperplasia and Prostate Cancer Tissues, Relation with Transcription, Growth Factors, Hormone Reception and Components of the AKT/mTOR Signaling Pathway.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception.Heliyon · 2019Review
- EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ.PloS one · 2017Article
- The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells.Cellular signalling · 2014Article
- The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.EMBO molecular medicine · 2013Article
- Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.Journal of cancer research and clinical oncology · 2011Article
- Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer.Journal of ovarian research · 2010Article
- A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction.The Journal of biological chemistry · 2010Article
- A kernel-based integration of genome-wide data for clinical decision support.Genome medicine · 2009Article
- Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells.Immunology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor in vitro (i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.