ArticleThe Journal of cell biology2005
IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Adult stem cell sources for skeletal and smooth muscle tissue engineering.Stem cell research & therapy · 2022Review
- The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury.Tissue engineering. Part A · 2019Article
- Muscle Stem Cells Exhibit Distinct Clonal Dynamics in Response to Tissue Repair and Homeostatic Aging.Cell stem cell · 2018Article
- Keratin Hydrogel Enhances In Vivo Skeletal Muscle Function in a Rat Model of Volumetric Muscle Loss.Tissue engineering. Part A · 2017Article
- Autonomous Extracellular Matrix Remodeling Controls a Progressive Adaptation in Muscle Stem Cell Regenerative Capacity during Development.Cell reports · 2016Article
- Gene and cell therapy for muscle regeneration.Current reviews in musculoskeletal medicine · 2015Article
- An Autologous Muscle Tissue Expansion Approach for the Treatment of Volumetric Muscle Loss.BioResearch open access · 2015Article
- Article
- Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: facts and perspectives.BioMed research international · 2014Review
- Systemic delivery of human mesenchymal stromal cells combined with IGF-1 enhances muscle functional recovery in LAMA2 dy/2j dystrophic mice.Stem cell reviews and reports · 2013Article
- Skeletal Muscle-derived Hematopoietic Stem Cells: Muscular Dystrophy Therapy by Bone Marrow Transplantation.Journal of stem cell research & therapy · 2012Article
- Article
- Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice.Experimental gerontology · 2011Article
- Human epicardium-derived cells fuse with high efficiency with skeletal myotubes and differentiate toward the skeletal muscle phenotype: a comparison study with stromal and endothelial cells.Molecular biology of the cell · 2011Article
- Isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice.PloS one · 2011Article
- Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- The origin, molecular regulation and therapeutic potential of myogenic stem cell populations.Journal of anatomy · 2009Review
- Article
- Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.Nature cell biology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Muscle damage has been shown to enhance the contribution of bone marrow-derived cells (BMDCs) to regenerating skeletal muscle. One responsible cell type involved in this process is a hematopoietic stem cell derivative, the myelomonocytic precursor (MMC). However, the molecular components responsible for this injury-related response remain largely unknown. In this paper, we show that delivery of insulin-like growth factor I (IGF-I) to adult skeletal muscle by three different methods-plasmid electroporation, injection of genetically engineered myoblasts, and recombinant protein injection-increases the integration of BMDCs up to fourfold. To investigate the underlying mechanism, we developed an in vitro fusion assay in which co-cultures of MMCs and myotubes were exposed to IGF-I. The number of fusion events was substantially augmented by IGF-I, independent of its effect on cell survival. These results provide novel evidence that a single factor, IGF-I, is sufficient to enhance the fusion of bone marrow derivatives with adult skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.