ArticleThe Journal of cell biology2005
MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 156 citations in OpenAlex.
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- Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia.Cell death discovery · 2024Article
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- Molecular Regulation of Porcine Skeletal Muscle Development: Insights from Research on CDC23 Expression and Function.International journal of molecular sciences · 2024Article
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- Muscle growth differences in Lijiang pigs revealed by ATAC-seq multi-omics.Frontiers in veterinary science · 2024Article
- Biomechanical Stimulation of Muscle Constructs Influences Phenotype of Bone Constructs by Modulating Myokine Secretion.JBMR plus · 2023Article
- A single-cell atlas of bovine skeletal muscle reveals mechanisms regulating intramuscular adipogenesis and fibrogenesis.Journal of cachexia, sarcopenia and muscle · 2023Article
- Developmental Characteristics of Skeletal Muscle during the Embryonic Stage in Chinese Yellow Quail (Animals : an open access journal from MDPI · 2023Article
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16.American journal of physiology. Cell physiology · 2023Article
- Review
- Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation.Cell death & disease · 2022Article
- Maternal nutrition altered embryonic MYOD1, MYF5, and MYF6 gene expression in genetically fat and lean lines of chickens.Animal bioscience · 2022Article
- Exploring high-resolution chromatin interaction changes and functional enhancers of myogenic marker genes during myogenic differentiation.The Journal of biological chemistry · 2022Article
- MiR-743a-5p regulates differentiation of myoblast by targetingGenes & diseases · 2022Article
- Article
- Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells.Cells · 2022Review
- Arginine promotes myogenic differentiation and myotube formation through the elevation of cytoplasmic calcium concentration.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MyoD and Myf5 are basic helix-loop-helix transcription factors that play key but redundant roles in specifying myogenic progenitors during embryogenesis. However, there are functional differences between the two transcription factors that impact myoblast proliferation and differentiation. Target gene activation could be one such difference. We have used microarray and polymerase chain reaction approaches to measure the induction of muscle gene expression by MyoD and Myf5 in an in vitro model. In proliferating cells, MyoD and Myf5 function very similarly to activate the expression of likely growth phase target genes such as L-myc, m-cadherin, Mcpt8, Runx1, Spp1, Six1, IGFBP5, and Chrnbeta1. MyoD, however, is strikingly more effective than Myf5 at inducing differentiation-phase target genes. This distinction between MyoD and Myf5 results from a novel and unanticipated cooperation between the MyoD NH2- and COOH-terminal regions. Together, these results support the notion that Myf5 functions toward myoblast proliferation, whereas MyoD prepares myoblasts for efficient differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.