ArticlePLoS biology2005
Ancient and recent positive selection transformed opioid cis-regulation in humans.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 198 citations in OpenAlex.
- Neuroimmune Mechanisms of Opioid Use Disorder and Recovery: Translatability to Human Studies, and Future Research Directions.Neuroscience · 2023Review
- The interaction engine: cuteness selection and the evolution of the interactional base for language.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain.Molecules (Basel, Switzerland) · 2021Review
- The Evolved Psychology of Psychedelic Set and Setting: Inferences Regarding the Roles of Shamanism and Entheogenic Ecopsychology.Frontiers in pharmacology · 2021Review
- Accelerated evolution at chaperone promoters among Antarctic notothenioid fishes.BMC evolutionary biology · 2019Article
- Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues.G3 (Bethesda, Md.) · 2019Article
- Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates.PLoS genetics · 2019Article
- Molecular windows into the human brain for psychiatric disorders.Molecular psychiatry · 2019Review
- Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Dynamic evolution of regulatory element ensembles in primate CD4Nature ecology & evolution · 2018Article
- Human Accelerated Regions and Other Human-Specific Sequence Variations in the Context of Evolution and Their Relevance for Brain Development.Genome biology and evolution · 2018Review
- The Mechanisms of Psychedelic Visionary Experiences: Hypotheses from Evolutionary Psychology.Frontiers in neuroscience · 2017Article
- Genome-Wide Identification of Regulatory Sequences Undergoing Accelerated Evolution in the Human Genome.Molecular biology and evolution · 2016Article
- Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa).Molecular biology and evolution · 2016Article
- Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent.Scientific reports · 2015Article
- A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.eLife · 2015Article
- Cis-regulatory elements and human evolution.Current opinion in genetics & development · 2014Review
- Evolutionary dynamics of coding and non-coding transcriptomes.Nature reviews. Genetics · 2014Review
- Fast evolution from precast bricks: genomics of young freshwater populations of threespine stickleback Gasterosteus aculeatus.PLoS genetics · 2014Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for a suite of endogenous opioids and neuropeptides with critical roles in regulating perception, behavior, and memory. Independent lines of phylogenetic and population genetic evidence support a history of selective sweeps driving the evolution of the human prodynorphin promoter. In experimental assays of chimpanzee-human hybrid promoters, the selected sequence increases transcriptional inducibility. The evidence for a change in the response of the brain's natural opioids to inductive stimuli points to potential human-specific characteristics favored during evolution. In addition, the pattern of linked nucleotide and microsatellite variation among and within modern human populations suggests that recent selection, subsequent to the fixation of the human-specific mutations and the peopling of the globe, has favored different prodynorphin cis-regulatory alleles in different parts of the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.