Evidence map›Paper›PMID 16273633›Full record

ArticleWorld journal of gastroenterology2005

Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population.

Roberto Herrera-Goepfert, Suminori Akiba, Chihaya Koriyama, Shan Ding, Edgardo Reyes, Tetsuhiko Itoh, Yoshie Minakami, Yoshito Eizuru

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 6 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Epstein-Barr Virus and Gastric Cancer Risk: A Meta-analysis With Meta-regression of Case-control Studies.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016
    Pooled it
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  7. Article
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  9. Review
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  12. Epstein-Barr Virus andPathogens (Basel, Switzerland) · 2020
    Review
  13. EBV Positive Gastric Carcinomas and Their Clinicopathological Characteristics.Open access Macedonian journal of medical sciences · 2018
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Gastric cancer research in Mexico: a public health priority.World journal of gastroenterology · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Roberto Herrera-GoepfertDepartamento de Patologia Instituto Nacional de Cancerologia, Av. San Fernando #22, Colonia Seccion XVI, Tlalpan, Mexico DF 14080, Mexico. rhgoepfert@yahoo.com.mx
Suminori Akiba
Chihaya Koriyama
Shan Ding
Edgardo Reyes
Tetsuhiko Itoh
Yoshie Minakami
Yoshito Eizuru
Kagoshima Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.

methodsCases of primary gastric adenocarcinoma were retrieved from the files of the Departments of Pathology at the Instituto Nacional de Cancerologia and the Instituto Nacional de la Nutricion in Mexico City. The anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1) in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.

resultsWe studied 330 consecutive, non-selected, primary gastric carcinomas. Among these, there were 173 male and 157 female patients (male/female ratio 1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.

conclusionAmong Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population.

Indexed as

AdultAgedAged, 80 and overAge DistributionEpstein-Barr Virus InfectionsFemaleHumansMaleMexicoMiddle AgedRisk FactorsStomach Neoplasms

Identifiers

PMID16273633
PMCPMC4436624
OpenAlexW2174989759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.