ArticleWorld journal of gastroenterology2005
Downregulation of alpha-fetoprotein siRNA inhibits proliferation of SMMC-7721 cells.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- alpha-Fetoprotein as a modulator of the pro-inflammatory response of human keratinocytes.British journal of pharmacology · 2009Article
- Transformation of human liver L-O2 cells mediated by stable HBx transfection.Acta pharmacologica Sinica · 2009Article
- Alpha-fetoprotein: A Multifaceted Player in Cancer Biology.Euroasian journal of hepato-gastroenterologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the function of alpha-fetoprotein (AFP) in SMMC-7721 hepatoma cells.
methodsA hairpin siRNA expressing plasmid pSilencer3.0-H1-afp was constructed and transfected into SMMC-7721 cells with Lipofectamine 2000. The expression of AFP was monitored by real-time RT-PCR and immunoassays, its effect on SMMC-7721 cell proliferation and cell death was detected by MTT and fluorescence activated cell sorter (FACS).
resultsThe AFP-siRNA expressing plasmid downregulated the expression of AFP obviously (about 34%), and inhibited SMMC-7721 cell proliferation, but did not induce apoptosis.
conclusionDownregulation of AFP siRNA inhibits proliferation of SMMC-7721 cells, but cannot cause apoptosis.
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Registered trials
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